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Schaffer, Chris
Associate Professor
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Positions
- Associate Professor, Biomedical Engineering (BME), College of Engineering
Research Areas
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- Service
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Affiliations
Research
principal investigator on
- A NOVEL FEMTOSECOND LASER-BASED SURGICAL THERAPY FOR NEOCORTICAL EPILEPSY awarded by NATL CTR FOR RESEARCH RESOURCES, NIH 2011 - 2012
- ALZHEIMER'S DISEASE LEADS TO INCREASED BLOOD FLOW STALLS IN BRAIN CAPILLARIES awarded by ALZHEIMER'S ART QUILT INITIATIVE 2011 - 2012
- CAREER: OPTICS IN BIOLOGICAL RESEARCH, EDUCATION, AND OUTREACH: ARRA FUNDED awarded by DIRECTORATE FOR ENGINEERING NSF 2009 - 2014
- EFFECTS OF POLYCYTHEMIA VERA ON CEREBRAL MISROCIRCULATION awarded by CANCER RESEARCH AND TREATMENT FUND 2011 - 2012
- FACILITY EQUIPMENT USE AGREEMENT awarded by IMRA AMERICA, INC. 2007 - 2013
- ROLE OF LEUKOCYTE ADHESION IN IMPAIRED CEREBRAL BLOOD FLOW IN ALZHEIMER'S DISEASE awarded by ALZHEIMER'S DRUG DISCOVERY FOUNDATION 2011 - 2012
- ROLE OF MICROVASCULAR LESIONS IN ALZHEIMER'S DISEASE awarded by NATL INST OF HEALTH DHHS 2012 - 2013
- SUBCONTRACT FROM UCSF: IN VIVO IMAGING OF BRAIN ARTERIO-VENUS MALFORMATION awarded by NATL INST OF HEALTH DHHS 2010 - 2013
co-principal investigator on
- BIOMECHANICAL REGULATION OF VALVULOGENESIS awarded by NATL HEART LUNG & BLOOD INST, NIH 2011 - 2016
- BRAIN ENDOTHELIAL CELL FUNCTION UNDER ADENOSINE RECEPTOR SIGNALING DIRECTIVE awarded by NATL INST OF NEUR DIS & STROKE, NIH 2012 - 2017
- CENTER ON THE MICROENVIRONMENT AND METASTASIS awarded by NATL CANCER INSTITUTE, NIH 2009 - 2014
- COLLABORATIVE CURRICULUM DEVELOPMENT: INTERDISCIPLINARY MIDDLE AND HIGH SCHOOL EDUCATION IN BIOMEDICAL ENGINEERING THROUGH GRADUATE STUDENT/TEACHER INTERACTION PROGRAM awarded by NATL SCIENCE FOUNDATION 2009 - 2014
- HISTOLOGY FOR LIFETIME BIO-ELECTRONIC INTERFACES: ACTIVE PROBES, IMAGING, AND QUANTIFICATION awarded by DEFENSE ADVANCED RESEARCH PROJECT AGENCY DOD 2010 - 2012
- NANOPARTICLE TRANSPORT IN THE BRAIN awarded by NATL SCIENCE FOUNDATION 2011 - 2014
- THE ROLE OF AGE-RELATED MATRIX STIFFENING ON ENDOTHELIAL CELL FUNCTION awarded by NATL HEART LUNG & BLOOD INST, NIH 2011 - 2012
- UNDERGRADUATE SCIENCE EDUCATION 2010 - CORE PROPOSAL awarded by HOWARD HUGHES MEDICAL INST 2010 - 2014
Publications
individual publications
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academic article
- Intravenous tPA Therapy Does Not Worsen Acute Intracerebral Hemorrhage in Mice. PLoS ONE. 8. 2013
- Chronic in vivo imaging in the mouse spinal cord using an implanted chamber. Nature Methods. 9:297-302. 2012
- Chronic in vivo imaging in the mouse spinal cord using an implanted chamber. Nature Methods. 9:297-302. 2012
- Cyclic strain anisotropy regulates valvular interstitial cell phenotype and tissue remodeling in three-dimensional culture. Acta Biomaterialia. 8:1710-9. 2012
- In vivo two-photon excited fluorescence microscopy reveals cardiac- and respiration-dependent pulsatile flow in cortical blood vessels in mice. American Journal of Physiology, Heart and Circulatory Physiology. 302. 2012
- Line-scanning particle image velocimetry: an optical for quantifying a wide range of blood flow speeds in live animals. PLoS ONE. 7. 2012
- Notch4 normalization reduces blood vessel size in arteriovenous malformations. Science Translational Medicine. 4. 2012
- Real-time imaging of perivascular transport of nanoparticles during convection enhanced delivery in the rat cortex. Annals of Biomedical Engineering. 40:292-303. 2012
- Two-photon microscopy as a tool to study blood flow and neurovascular coupling in the rodent brainon of blood flow at the level of single microvessels in rodent cortex. Journal of Cerebral Blood Flow and Metabolism. 32:1277-309. 2012
- Age-related intimal stiffening enhances endothelial permeability and leukocyte transmigration. Science Translational Medicine. 3. 2011
- Anticoagulation with the oral direct thrombin inhibitor dabigatran does not enlarge hematoma volume in experimental intracerebral hemorrhage. Circulation. 124:1654. 2011
- Cortical microhemorrhages cause local inflammation but do not trigger dendrite pathology. PLOS One. 6. 2011
- Cortical microhemorrhages cause local inflammation but do not trigger widespread dendrite degeneration. PLoS ONE. 6. 2011
- In vivo imaging of myelin in the vertebrate central nervous system using third harmonic generation microscopy. Biophysical Journal. 100:1362-1371. 2011
- Occlusion of cortical ascending venules causes blood flow decreases, reversals in flow direction, and vessel dilation in upstream capillaries. Journal of Cerebral Blood Flow and Metabolism. 31. 2011
- Optically quantified cerebral blood flow. Journal of Cerebral Blood Flow and Metabolism. 31. 2011
- Pre-ictal and ictal neurovascular and metabolic coupling surrounding a seizure focus. Journal of Neuroscience. 31:13292-13300. 2011
- Sub-surface, micrometer-scale incisions produced in rodent cortex using tightly-focused femtosecond laser pulses. Lasers in Surgery and Medicine. 43:382-391. 2011
- Limitations of collateral flow after occlusion of a single cortical penetrating arteriole. Journal of Cerebral Blood Flow and Metabolism. 30:1914-1927. 2010
- Two-photon microscopy-guided femtosecond-laser photoablation of avian cardiogenesis: noninvasive creation of localized heart defects. Am J Physiol Heart Circ Physiol. 299. 2010
- Blood flow in cortical microvascular networks at normal and high hematocrit. Journal of Cerebral Blood Flow and Metabolism. 29. 2009
- Deep tissue multiphoton microscopy using longer wavelength excitation. Optics Express. 17:13354-13364. 2009
- Flexible microfluidic devices supported by biodegradable insertion scaffolds for convection-enhanced neural drug delivery. Biomedical Microdevices. 11:915-924. 2009
- Light and matter interactions: Going with the grain. Nature Photonics. 2:73. 2008
- Large two-photon absorptivity of hemoglobin in the infrared range of 780-800 nm. Journal of Chemical Physics. 126:025102. 2007
- Penetrating arterioles: A bottleneck in the perfusion of cortex. PNAS. 104:365-370. 2007
- Photonic band-gap fiber gas cell fabricated using femtosecond micromachining. Optics Express. 15:6690-6695. 2007
- Numerical aperture dependence of damage and supercontinuum generation from femtosecond laser pulses in bulk fused silica. Journal of the Optical Society of America B. 23:2317-2322. 2006
- Spectroscopic analysis of the oxygenation state of hemoglobin using coherent anti-Stokes Raman scattering. Journal of Biomedical Optics. 11:050502. 2006
- Spectroscopy of third-harmonic generation: evidence for resonances in model compounds and ligated hemoglobin. Journal of the Optical Society of America B. 23:932-950. 2006
- Targeted insult to subsurface cortical blood vessels using ultrashort laser pulses: Three models of stroke. Nature Methods. 3:99-108. 2006
- Two-photon imaging of cortical surface microvessels reveals a robust redistribution in blood flow after vascular occlusion. Public Library of Science: Biology. 4. 2006
- Ultrafast processes for bulk modification of transparent materials. Materials Research Society Bulletin. 31:620-625. 2006
- Ablation of cytoskeletal filaments and mitochondria in live cells using a femtosecond laser nanoscissor. Mechanics and Chemistry of Biosystems. 2:17-25. 2005
- Femtosecond laser-drilled capillary integrated into a microfluidic device. Applied Physics Letters. 86. 2005
- Beyond observation: microscopy with ultrashort laser pulses to probe and manipulate cortical vasculature. SPIE Optics in Information Systems. 15:4. 2004
- Heterogeneous changes in blood flow in response to single-vessel blockages and MCA occlusion in rat parietal cortex as revealed by in vivo two-photon laser imaging.. Stroke. 35:81. 2004
- Morphology of femtosecond laser-induced structural changes in bulk transparent materials. Applied Physics Letters. 84:1441-1443. 2004
- All-optical histology using ultrashort laser pulses. Neuron. 39:27-41. 2003
- Bulk heating of transparent materials using a high repetition-rate femtosecond laser. Applied Physics. 76:351-354. 2003
- Customization of poly(dimethylsiloxane) stamps by micromachining using a femtosecond-pulsed laser. Advanced Materials. 15:62-65. 2003
- Microexplosions in tellurite glasses. Applied Physics A. 76:379. 2003
- Dynamics of femtosecond laser-induced breakdown in water from femtoseconds to microseconds. Optics Express. 10:196-203. 2002
- Laser-induced breakdown and damage in bulk transparent materials using tightly-focused femtosecond laser pulses. Measurement Science and Technology. 12:1784-1794. 2001
- Micromachining and optical device fabrication using ultrashort pulses from a laser oscillator. Optics and Photonics News. 12:20. 2001
- Micromachining bulk glass by use of femtosecond laser pulses with nanojoule energy. Optics Letters. 26:93-5. 2001
- Time-decorrelated multifocal micromachining and trapping. IEEE Journal of Selected Topics in Quantum Electronics. 7:559-566. 2001
- Minimally disruptive laser-induced breakdown in water. Optics Letters. 22:1817-1819. 1997
- Programmable shaping of ultrabroad-bandwidth pulses from a Ti:Sapphire laser. Journal of the Optical Society of America B. 12:1968-1980. 1995
-
chapter
- Pioneering applications of two-photon microscopy to mammalian neurophysiology: seven case studies. Handbook of Biolomedical Nonlinear Optical Microscopy. 715. 2008
- All-optical, in situ histology of neuronal tissue with femtosecond laser pulses. Imaging in Neuroscience and Development: A Laboratory Manual. 439. 2005
- Structural changes induced in transparent materials with ultrashort laser pulses. Ultrafast lasers: technology and applications. 395. 2003
- Non-perturbative up-conversion techniques: Ultrafast meets X-rays. Ultrafast Dynamics of Quantum Systems: Physical Processes and Spectroscopic Techniques. 611. 1999
-
conference paper
- Optical tools to produce and study small strokes in animal models. Conference Proceeding of IEEE Engineering in Medicine and Biology Society. 2010
- Stimulus-evoked calcium transients in somatosensory cortex are inhibited after a nearby microhemorrhage. Technical Digest: OSA Biomedical Optics Meeting. 2010
- Third harmonic generation as a novel technique for imaging myelin in the central nervous system. Technical Digest: OSA Biomedical Optics Meeting. 2010
- Ablation of the Mauthner cell lateral dendrite using femtosecond laser pulses. Technical Digest: OSA Annual Meeting. 2008
- Femtosecond laser-driven photodisruption to induce single venule occlusions in rodent brain. Technical Digest: OSA Annual Meeting. 2008
- Femtosecond laser-induced microvascular clots trigger Alzheimer’s disease pathology. Technical Digest: OSA Annual Meeting. 2008
- In vivo manipulation of biological systems with femtosecond laser pulses. High Power Laser Ablation VI. 2006
- Three-dimensional micromachining inside transparent materials using femtosecond laser pulses: new applications. Technical Digest: OSA Conference on Lasers and Electro-Optics. 2006
- Ultrafast third harmonic micro-spectroscopy reveals a two-photon resonance in human hemoglobin. Proceedings of SPIE Vol. 6108 Commercial and Biomedical Applications of Ultrafast Lasers VI. 2006
- Targeted disruption of deep-lying neocortical microvessels in rat using ultrashort laser pulses. Proceedings of SPIE Vol. 5340 Commercial and Biomedical Applications of Ultrafast Lasers IV. 179. 2004
featured in archived article
Teaching
teaching activities
- BME-4900: Independent Undergraduate Project in Biomedical Engineering - Spring 2013
- BME-4900: Independent Undergraduate Project in Biomedical Engineering - Fall 2012
- BME-8600: Doctoral Research Rotations in Biomedical Engineering - Fall 2012
- BME-4900: Independent Undergraduate Project in Biomedical Engineering - Spring 2012
- BME-7130: Core Concepts in Disease - Spring 2012
- VTMED-6399: Research Opportunities in Veterinary Medicine - Spring 2012
- BME-4110: Science and Technology Approaches to Problems in Human Health - Fall 2011
- BME-4900: Independent Undergraduate Project in Biomedical Engineering - Fall 2011
- BME-8600: Doctoral Research Rotations in Biomedical Engineering - Fall 2011
- ENGRG-1050: Engineering Seminar - Fall 2011
Service
reviewer or editor for
- Alzheimer’s Association
- Applied Optics
- Applied Physics B
- Applied Physics Letters
- BMC Biotechnology
- Biomedical Optics Division, Optical Society of America Board of Meetings
- Congressionally Directed Medical Research Program on Epilepsy
- Frontiers in Neuroenergetics
- IEEE Journal of Quantum Electronics
- Journal of Applied Physics
- Journal of Biomedical Optics
- Journal of Cerebral Blood Flow and Metabolism
- Journal of Neuroscience
- Journal of Neuroscience Methods
- Journal of Optical Materials
- Journal of the Optical Society of America B
- National Science Foundation BISH panel
- National Science Foundation MRI-R2 panel
- Nature Medicine
- Nature Photonics
- Nature Protocols
- NeuroImage
- Optical Society of America Laser Microfabrication topical meeting
- Optics Communications
- Optics Express
- Optics Letters
- Physical Review Letters
- Proceedings of the National Academy of Sciences
- Stroke
Background
education and training
- Ph.D. in Physics, Harvard University 2001
- B.S. in Physics, University of Florida; Florida 1995
awards and honors
- Arthur H. Guenther Congressional Science Policy Fellowship, 2013
- Zellman Warhaft Committment to Diversity Faculty Award, 2010
- CAREER award, 2009
- Biomedical Engineering Teaching Award, 2009
- Dorothy G. Swanson Excellence in Teaching Award, 2008
- Scientist Development Grant, 2007
- New Scholar in Aging Award, 2006
- La Jolla Interfaces in Science Post-Doctoral Fellowship, 2002
- New Focus Student Award, top prize, 2000
- Apker Award, 1996
- National Defense Science and Engineering Graduate Fellowship, 1996
- Outstanding Four Year Scholar, 1995
- Phi Beta Kappa, Academic Honor Society, 1994
Other
college
- ENG
name prefix
- Professor