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Vatamaniuk, Olena K
Cornell Faculty Member
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Positions
- Associate Professor, Crop and Soil Sciences (CSS), College of Agriculture and Life Sciences (CALS)
Olena Vatamaniuk is Associate Professor of Molecular Biology of Abiotic Stress in the Department of Crop and Soil Sciences at Cornell University. She earned her bachelor’s degree in Botany at Lviv State University, Ukraine in 1992 and Ph.D. in Plant Physiology at Lviv State and Kyiv State Universities, Ukraine. Driven by the desire to extend her expertise from physiology to molecular biology and biochemistry she joined Dr. Phil Rea’s group at the University of Pennsylvania, USA for postdoctoral studies were she focused on molecular mechanisms of phytochelatin-dependent heavy metal detoxification in plants. Finding that the phytochelatin-dependent pathway, formerly suggested to be restricted to plants and some fungi, operates in at least some animals, the nematode worm Caenorhabditis elegans, prompted her to gain additional expertise in C. elegans biology, at the Department of Genetics of University of Pennsylvania. She joined the Cornell faculty in 2005. Her research program focuses on analyses of transition metals homeostasis and crosstalk between essential and toxic metals in plants and C. elegans.
Research Areas
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Affiliations
Research
research activities
- Analyses of biochemical and genetic interactions of ABC transporters required for heavy metal detoxification in C. elegans
- Analyses of the molecular mechanisms of HMT-1-dependent heavy metal detoxification
- Novel tools for remediation of heavy metal contaminated soil and water using transgenic plants
principal investigator on
submitted impact statement
- Understanding of mechanisms and sites of heavy metal detoxification in humans: molecular genetic and biochemical studies of a half molecule ATP-binding cassette (ABC) transporter, CeHMT-1, function in heavy metal detoxification:
- Novel tools for remediation of heavy metal-contaminated soil and water using transgenic plants.
- Novel tools for remediation of heavy metal-contaminated soil and water using transgenic plants.
- Analyses of the molecular mechanisms of HMT-1-dependent heavy metal detoxification
Publications
individual publications
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academic article
- COPT6 is a Plasma Membrane Transporter that Functions in Copper Homeostasis in Arabidopsis and is a Novel Target of SQUAMOSA Promoter Binding Protein-Like 7.. Journal of Biological Chemistry. 287:33252-33267. 2012
- High-resolution genome-wide scan of genes, gene-networks and cellular systems impacting the yeast ionome.. BMC Genomics. 13:623. 2012
- Direct Transfer of Synthetic Double-Stranded RNA into Protoplasts of Arabidopsis thaliana. Methods in Molecular Biology. 744:109-127. 2011
- Noise reduction in genome-wide perturbation screens using linear mixed-effect models. Bioinformatics. 27:2173-2180. 2011
- Detoxification of multiple heavy metals by a half-molecule ABC transporter HMT-1 and coelomocytes of Caenorhabditis elegans. PLoS One. 5. 2010
- Schizosaccharomyces pombe Abc2p mediates phytochelatin accumulation in vacuoles and confers cadmium tolerance. Journal of Biological Chemistry. 285:40416-40426. 2010
- The N-terminal extension domain of the C. elegans half-molecule ABC transporter, HMT-1, is required for protein-protein interactions and function. PLoS One. 5. 2010
- The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans. Development. 137:2375-2384. 2010
- Drosophila ABC transporter, DmHMT-1, confers tolerance to cadmium. Journal of Biological Chemistry. 284:354-362. 2009
- Establishing RNAi as a reverse genetic approach for gene functional analysis in protoplasts.. Plant Physiology. 149:642-52. 2009
- Isolation of protoplasts from tissues of 14- days-old seedlings of Arabidopsis thaliana.. Journal of Visual Experiments. 17:1149. 2009
- Null of Se-glutathione peroxidase-1 (GPX1) or Cu,Zn-superoxide dismutase (SOD1) suppresses murine pancreatic insulin synthesis and secretion. FASEB Journal. 22. 2008
- Mutagenic definition of a papain-like catalytic triad, sufficiency of the N-terminal domain for single-site core catalytic enzyme acylation, and C-terminal domain for augmentative metal activation of a eukaryotic phytochelatin synthase.. Plant Physiology. 141:858-69. 2006
- CeHMT-1, a putative phytochelatin transporter, is required for cadmium tolerance in Caenorhabditis elegans.. Journal of Biological Chemistry. 280:23684-23690. 2005
- Phytochelatin synthase, a dipeptidyltransferase that undergoes multisite acylation with gamma-glutamylcysteine during catalysis: stoichiometric and site-directed mutagenic analysis of arabidopsis thaliana PCS1-catalyzed phytochelatin synthesis.. Journal of Biological Chemistry. 279:22449-60. 2004
- Weeds, worms, and more. Papain's long-lost cousin, phytochelatin synthase.. Plant Physiology. 136:2463-74. 2004
- Acetylcholine affects rat liver metabolism via type 3 muscarinic receptors in hepatocytes.. Life Science. 72:1871-82. 2003
- Worms take the 'phyto' out of 'phytochelatins'. Trends Biotechnology. 20:61-64. 2002
- A new pathway for heavy metal detoxification in animals. Phytochelatin synthase is required for cadmium tolerance in Caenorhabditis elegans.. Journal of Biological Chemistry. 276:20817-20. 2001
- Mechanism of heavy metal ion activation of phytochelatin (PC) synthase: blocked thiols are sufficient for PC synthase-catalyzed transpeptidation of glutathione and related thiol peptides.. Journal of Biological Chemistry. 275:31451-9. 2000
- AtPCS1, a phytochelatin synthase from Arabidopsis: isolation and in vitro reconstitution.. Proceedings at the National Academy of Science USA. 96:7110-5. 1999
- The intensity of protein synthesis in cells of corn root meristems under the influence of ABA and hypothermic conditions. Ukrayinski Botanichnyi Zhurnal. 1:54-61. 1997
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conference paper
- Increase in the activity of abscisic acid and cytokinins and protein synthesis in cells of corn root meristems during low temperature stress. Proceedings of Conference on Progress in Plant Science: From Plant Breeding to Growth Regulation. 23-28. 1996
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document part
- A Subtractive Microarray Analysis Revealed that a Putative Copper Transporter of Arabidopsis, COPT2, Functions in Cadmium Detoxification 2010
- An oligopeptide transporter of Arabidopsis, AtOPT3, functions in Cd detoxification 2010
- Isolation and Transfection of Protoplasts from Brachypodium distachyon for Subsequent Studies of Cell Wall Biogenesis Machinery 2010
- Systematic Studies of ABC Transporters Function in Cadmium Detoxification 2010
- The N-Terminal Extension of a Half-Molecule ABC Transporter, HMT-1, is Required for its Protein-Protein Interactions and Function in Cadmium Detoxification 2010
- “Novel” Functions of “Old” Transporters: COPT2 and OPT3 function in cadmium detoxification in Arabidopsis thaliana 2010
- Detection and genetic analysis of polyembryonic pale swallow-wort seeds.. 22. 2009
- Determination of genetic similarity between embryos in polyembryonic Vincetoxicum rossicum (pale swallow-ort) seeds. 96. 2008
- CeHMT-1, a putative phytochelatin transporter, is required for cadmium tolerance in Caenorhabditis elegans 2005
- Ectopic expression of bacterial genes encoding glutathione synthetic enzymes increases the capacity of Arabidopsis thaliana AtPCS1 transgenics for PC biosynthesis and accumulation. Analysis of tissue distribution of the expression and subcellular localization of AtPCS1 fusions. 2002
- Worms take the ‘phyto’ out from phytochelatins 2001
- Heavy metal ions are not essential for phytochelatin (PC) synthesis by PC synthase 2000
- Is phytochelatin synthase a dipeptidyl or tripeptidyl transpeptidase? 2000
- Enzymatic properties of phytochelatin synthase (γ-glutamylcysteine dipeptidyl transpeptidase) from Arabidopsis 1999
- Molecular cloning of phytochelatin synthase from Arabidopsis and in vitro reconstitution of the catalysis 1999
- AtCRF1, a novel multispecific heavy metal resistance factor from Arabidopsis 1998
presentations
featured in archived article
speaker at Cornell event
Teaching
teaching activities
- BIOPL-6420: Mineral Nutrition: From Plants to Humans - Spring 2013
- BIOPL-7490: Graduate Research in Botany - Spring 2013
- CSS-6420: Mineral Nutrition: From Plants to Humans - Spring 2013
- CSS-6980: Graduate Teaching or Extension Experience - Spring 2013
- CSS-7910: Graduate-Level Thesis Research in Crop Science - Spring 2013
- CSS-7970: Graduate Individual Study in Crop and Soil Science - Spring 2013
- CSS-8900: Master's Level Thesis Research in Crop Science - Spring 2013
- CSS-9910: Doctoral-Level Dissertation Research in Crop Science - Spring 2013
- TOX-8900: Master's Thesis and Research - Spring 2013
- TOX-9900: Doctoral Thesis and Research - Spring 2013
- BIOPL-7490: Graduate Research in Botany - Fall 2012
- CSS-6980: Graduate Teaching or Extension Experience - Fall 2012
- CSS-7910: Graduate-Level Thesis Research in Crop Science - Fall 2012
- CSS-7970: Graduate Individual Study in Crop and Soil Science - Fall 2012
- CSS-8900: Master's Level Thesis Research in Crop Science - Fall 2012
- CSS-9910: Doctoral-Level Dissertation Research in Crop Science - Fall 2012
- TOX-8900: Master's Thesis and Research - Fall 2012
- TOX-9900: Doctoral Thesis and Research - Fall 2012
- BIOPL-7490: Graduate Research in Botany - Spring 2012
- CSS-6980: Graduate Teaching or Extension Experience - Spring 2012
- CSS-7910: Graduate-Level Thesis Research in Crop Science - Spring 2012
- CSS-7970: Graduate Individual Study in Crop and Soil Science - Spring 2012
- CSS-8900: Master's Level Thesis Research in Crop Science - Spring 2012
- CSS-9910: Doctoral-Level Dissertation Research in Crop Science - Spring 2012
- TOX-8900: Master's Thesis and Research - Spring 2012
- TOX-9900: Doctoral Thesis and Research - Spring 2012
- BIOPL-7420: Current Papers in Plant Biology - Fall 2011
- BIOPL-7490: Graduate Research in Botany - Fall 2011
- CSS-6980: Graduate Teaching or Extension Experience - Fall 2011
- CSS-7910: Graduate-Level Thesis Research in Crop Science - Fall 2011
- CSS-7970: Graduate Individual Study in Crop and Soil Science - Fall 2011
- CSS-8900: Master's-Level Thesis Research in Crop Science - Fall 2011
- CSS-9910: Doctoral-Level Dissertation Research in Crop Science - Fall 2011
- TOX-8900: Master's Thesis and Research - Fall 2011
- TOX-9900: Doctoral Thesis and Research - Fall 2011
Service
service to the profession
- American Society for Biochemistry and Molecular Biology Member 2008 -
- Crop Science Society of America Member 2007 -
- Genetic Society of America Member 2007 -
- The American Society of Plant Biologists Member 1999 -
- Merit Research Associateship Member 2002 - 2004
reviewer or editor for
- Frontiers in Plant Traffic and Transport
- NSF Molecular and Cellular Systems, NSF Integrative Organismal Systems USDA-AFRI Plant Biology Environmental Stress, The National Science Foundation and the Louisiana Board of Regents Pfund
- NSF Physiological and Structural Systems, NSF Integrative Organismal Systems
- The National Science Foundation and the Louisiana Board of Regents Fund
Background
education and training
- Ph.D. in, Kyiv State University 1997
- Lviv State University 1992
awards and honors
- Best Junior Faculty Poster, 2009
- Nominated for Young Crop Scientist Award, 2008
- International Travel Grant, 2007
- Travel Grant, 2006
- Merit Research Associateship, 2002
- Travel Grant, 1999
- Travel Grant, 1998
- B.S./M.S. with First Class Honors, 1992
Other
alternate name
- Sekh
college
- CALS
name prefix
- Dr.