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Boisclair, Yves R
Cornell Faculty Member
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Research Areas
- animal science
- biochemistry
- biotechnology
- dairy science
- genomics
- molecular biology
- nutritional sciences
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Affiliations
Research
research overview
- The overall goal of my research program is to understand the regulation of metabolism, growth and development by hormones. We pursue this goal at molecular, cellular and organismal levels in the context of problems relevant to animal agriculture and medicine. At the present time, my research efforts are focused on 3 specific areas. 1) Hormonal coordination of metabolism in energy deficient ruminants: Dairy cattle experience dramatic changes in metabolism during the period from pregnancy to lactation when they enter a period of severe nutritional insufficiency. The goal of this research program is to identify the roles of growth hormone (GH) and leptin in inducing beneficial adaptations in the early lactating dairy cows. 2) Effect of fetal under-nutrition on postnatal energy metabolism: Epidemiological studies of human populations link fetal under-nutrition to juvenile obesity and chronic diseases during adult life. The goal of this research is to identify causal relation between intrauterine under-nutrition, impaired fetal hypothalamic development and postnatal obesity using a sheep model. 3) Regulation and function of vascular insulin-like growth factors (IGF-I): IGF-I is necessary for normal body growth and for the development of specific tissues (muscle, bone, mammary gland, etc) and is involved in diseases such as cancer and diabetes and in the aging process. The goal of this research is to identify the role played by liver derived IGF-I in various genetically engineered mice models subjected to anabolic or catabolic conditions.
principal investigator on
area(s) of concentration/expertise
keywords
- Hormone
- cattle
- growth
- growth hormone
- insulin-like growth factor
- lactation
- leptin
- metabolism
- mouse
- sheep
submitted impact statement
Publications
individual publications
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academic article
- Adiponectin deficit during the precarious glucose economy of early lactation in dairy cows.. Endocrinology. 153:5834-5844. 2012
- Large-scale preparation and characterization of non-pegylated and pegylated superactive ovine leptin antagonist.. Protein Expression and Purification. 81:166-192. 2012
- Non-synonymous natural genetic polymorphisms in the bovine leptin gene affect biochemical and biological characteristics of the mature hormone. . Journal of Animal Science. 90:410-418. 2012
- Effect of the prolactin-release inhibitor quinagolide on lactating dairy cows. Journal of Dairy Science. 94:1302-1309. 2011
- Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-α and leptin, and adipose tissue gene expression. Journal of Dairy Science. 94:5523-5532. 2011
- Plasma FGF21 is elevated by the intense lipid mobilization of lactation. Endocrinology. 152:4652-4661. 2011
- Prepartum dietary energy intake affects metabolism and health during the periparturient period in primiparous and multiparous Holstein cows. Journal of Dairy Science. 94:1385-1400. 2011
- Deletion of thyroid hormone responsive spot 14 exacerbates the anti-lipogenic affect of trans-10, cis-12 Conjugated Linoleic acid (CLA) in the mammary gland. Journal of Dairy Science. 93. 2010
- Effect of fish oil supplementation on mammary lipogenesis in mice. FASEB Journal. 24. 2010
- Effects of heat stress and nutrition on lactating Holstein cows: II. Aspects of hepatic growth hormone responsiveness. Journal of Dairy Science. 93:170-179. 2010
- Effects of t10, c12 CLA on mammary development, adiposity and inflammation in mice. Journal of Dairy Science. 93. 2010
- Mammary ductal growth is impaired in mice lacking leptin-dependent signal transducer and activator of transcription 3 signaling. Endocrinology. 151:3985-3995. 2010
- Prepartum 2,4-thiazolidinedione alters gene expression of peroxisome proliferator-activated receptor gamma and leptin in the adipose tissue of dairy cows. Journal of Dairy Science. 93:82. 2010
- The full-length isoform of the mouse pleckstrin homology domain-interacting protein (PHIP) is required for postnatal growth. FEBS Letters. 584:4121-4127. 2010
- t10,c12-CLA decreases adiposity in peripubertal mice without dose-related detrimental effects on mammary development, inflammation status and metabolism. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 299:1521-1528. 2010
- Impact of postpartum milking frequency on the immune system and blood metabolite concentration of dairy cows. Journal of Dairy Science. 92:1900-1912. 2009
- Leptin concentrations and the immune-mediated reduction of feed intake in sheep with the nematode Trichostrongylus colubriformis. British Journal of Nutrition. 102:954-957. 2009
- Recent advances in the regulation of milk fat synthesis. Animal. 3:40-54. 2009
- Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB Journal. 23:709-719. 2009
- The acid-labile subunit is required for full effects of exogenous growth hormone on growth and carbohydrate metabolism. Endocrinology. 150:5145-5152. 2009
- Growth hormone signaling in the regulation of acid labile subunit. Asian-Aust.J. Anim. Sci.. 21:754-768. 2008
- Increased degradation of insulin-like growth factor-I in serum from feed-deprived steers. Domestic Animal Endocrinology. 35:343-351. 2008
- Insulin regulates hepatic leptin receptor expression in early lactating dairy cows. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 295. 2008
- Regulation of mammary parenchymal growth by the fat pad in prepubertal dairy heifers: role of inflammation-related proteins. Journal of Endocrinology. 196:539-546. 2008
- Effect of estrogen on leptin and expression of leptin receptor transcripts in prepubertal dairy heifers. Journal of Dairy Science. 90:3742-3750. 2007
- Effect of feed restriction during calfhood on serum concentrations of metabolic hormones, gonadotrophin, testosterone, and on sexual development in bulls. Reproduction. 134:171-181. 2007
- Effect of nutrition on the growth hormone responsiveness of liver and adipose tissue in dairy cows. Journal of Endocrinology. 195:49-58. 2007
- Ontogenic and nutritional regulation of steroid receptor and IGF-I transcript abundance in the prepubertal heifer mammary gland. Journal of Endocrinology. 195:59-66. 2007
- Regulation of gene expression in the bovine mammary gland by ovarian steroids. Journal of Dairy Science. 90 Supplement 1. 2007
- The leptin arg25cys affects performance, carcass traits, and serum leptin concentrations in beef cattle. Canadian Journal of Animal Science. 87:153-156. 2007
- Estrogen-dependent responses of the mammary fat pad in prepubertal dairy heifers. Journal of Endocrinology. 190:819-827. 2006
- Identification of estrogen-responsive genes in the parenchyma and fat pad of the bovine mammary gland by microarray analysis. Physiological Genomics. 27:42-53. 2006
- Isolation of the cDNA encoding the acid labile subunit (ALS) of the 150 kDa IGF-binding protein complex in cattle and ALS regulation during the transition from pregnancy to lactation. Journal of Endocrinology. 189:583-593. 2006
- Leptin does not act directly on mammary epithelial cells in prepubertal dairy heifers. Journal of Dairy Science. 89:1467-1477. 2006
- Propionate is not an important regulator of plasma leptin concentration in dairy cattle. Domestic Animal Endocrinology. 30:65-75. 2006
- The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. Journal of Endocrinology. 189:289-99. 2006
- Acid-labile subunit deficiency: Phenotypic similarities and differences between human and mouse. J. Endocrinol. Invest. 28 (Supplement 5):43-46. 2005
- Firing up mitochondrial activities with PTPMTI. Molecular Cell. 19:291-292. 2005
- Dairy cows experience selective reduction of the hepatic growth hormone receptor during the periparturient period. Journal of Endocrinology. 18:281-290. 2004
- Insulin increases the abundance of the growth hormone receptor in liver and adipose tissue of periparturient dairy cows. Journal of Nutrition. 134:1020-1027. 2004
- Demonstration of a role for insulin in the regulation of leptin in lactating dairy cows. Journal of Dairy Science. 86:3508-3515. 2003
- Development and testing of a high-density cDNA microarray resource for cattle. American Journal of Physiology: Physiological Genomics. 15:158-164. 2003
- Development and testing of a high-density cDNA microarray resource for cattle. Physiological Genomics. 15:158-164. 2003
- Effect of insulin and growth hormone on plasma leptin in periparturient dairy cows. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 285. 2003
- Insulin resistance in the liver-specific IGF-1 gene deleted mouse is abrogated by deletion of the acid-labile subunit of the IGF-binding protein-3 complex: relative roles of growth hormone and IGF-I in insulin resistance. Diabetes. 52:2483-2489. 2003
- Nutritional and developmental regulation of plasma leptin in dairy cattle. Journal of Dairy Science. 86:3206-3214. 2003
- Plasma leptin is regulated predominantly by nutrition in preruminant lambs. Journal of Nutrition. 133:4196-4201. 2003
- Protein tyrosine phosphatase-1B attenuates growth hormone-mediated JAK2-STAT signaling. Molecular and Cellular Biology. 23:3753-3762. 2003
- The housekeeping genes GAPDH and cyclophilin are regulated by metabolic state in the liver of dairy cows. Journal of Dairy Science. 86:3423-3429. 2003
- Circulating levels of IGF-I directly regulate bone growth and density. The Journal of Clinical Investigation. 110:771-781. 2002
- Spatial and developmental regulation of leptin in fetal sheep. American Journal of Physiology. 282. 2002
- Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance. Journal of Endocrinology. 171:339-348. 2001
- Leptin and the regulation of food intake, energy homeostasis and immunity with special focus on periparturient ruminants. Dom. Anim. Endocrinol.. 21:215-250. 2001
- Maternal leptin is elevated during pregnancy in sheep. Dom. Anim. Endocrinol.. 21:85-96. 2001
- Regulation of the acid-labile subunit of the 150 kDa IGF-binding protein complex and its role in the circulating IGF system. Journal of Animal Science. 79. 2001
- The acid-labile subunit (ALS) of the 150 kDa IGF-binding complex: an important but forgotten component of the circulating IGF system. Journal of Endocrinology. 170:63-70. 2001
- Conservation of a growth hormone-responsive promoter element in the human and mouse acid-labile subunit genes. Endocrinology. 141:833-838. 2000
- Development of a specific RIA to measure physiological changes of circulating leptin in cattle and sheep. Journal of Endocrinology. 166:519-528. 2000
- Inactivation of the acid labile subunit gene in mice results in mild retardation of postnatal growth despite profound disruptions in the circulating insulin-like growth factor system. Proceedings of the National Academy of Sciences (PNAS). 97:6868-6873. 2000
- Insulin-like growth factor I (IGF-I) and cyclic adenosine 3’,5’-monophosphate regulate IGF-Binding protein-3 gene expression by transcriptional and posttranscriptional mechanisms in mammary epithelial cells. Endrocrinology. 141:4583-4591. 2000
- Nutritional regulation of the genes encoding the acid labile subunit and other components of the circulating insulin-like growth factor system in the sheep. Journal of Animal Science. 78:2681-2689. 2000
- Organization and regulation of the gene encoding the sheep acid labile subunit of the 150 kDa-binding protein complex. Endocrinology. 141:1425-1433. 2000
- Regulation and role of the acid labile subunit of the 150 kDa complex in the mouse. Pediatric Nephrology. 14:562-566. 2000
- Role of the suppressor of cytokine signaling-3 (SOC3) in mediating the inhibitory effects of interleukin-1 beta on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells. Journal of Biological Chemistry. 275:3841-3847. 2000
- Binding of Stat5a and Stat5b to a single element resembling a interferon activated sequence (GAS) mediates the growth hormone induction of the mouse acid-labile subunit promoter in liver cells. Molecular Endocrinology. 12:675-687. 1998
- Growth hormone stimulates transcription of the gene encoding the acid-labile subunit (ALS) of the circulating insulin-like growth factor binding protein complex and ALS promoter activity in rat liver. Molecular Endocrinology. 11:997-1007. 1997
- Paradoxical increases of circulating nonesterified fatty acids in somatotropin-treated steers undergoing mild disturbances. Domestic Animal Endocrinology. 14:251-262. 1997
- Cloning and characterization of a functional promoter of the rat pp120 gene, encoding a substrate of the insulin receptor tyrosine kinase. Journal of Biological Chemistry. 271:8809-8817. 1996
- Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex. Proceedings at the National Academy of Science USA. 93:10028-10033. 1996
- Effect of bovine somatotropin and insulin on whole body and hind-limb glucose metabolism in the growing steer. Journal of Animal Science. 73:2263-2271. 1995
- Structure and regulation of the ALS gene. Prog. Growth Factor Res.. 6:151-157. 1995
- Use of reverse ligation-PCR to identify the transcription start sites in GC-rich TATA-less genes: Application to the rat IGFBP-2 gene. DNA and Cell Biology. 14:731-739. 1995
- Effect of somato¬tropin on nutrient utilization and protein turnover in the hindlimb of cattle. Journal of Nutrition. 124:664-673. 1994
- IGF-I and insulin stimulates insulin like-growth factor binding protein-2 (IGFBP-2) synthesis in a human embryonic kidney cell line. Growth Regulation. 4:136-146. 1994
- Nutrient utilization and protein turnover in the hindlimb of cattle treated with bovine somatotropin. Journal of Nutrition. 124:664-673. 1994
- Chronic catheterization of external iliac vessels in growing cattle. Journal of Applied Physiology. 74:444-449. 1993
- Evaluation of the arteriovenous difference technique to simultaneously estimate protein synthesis and degradation in the hindlimb of fed and chronically underfed steers. Journal of Nutrition. 123:1076-1088. 1993
- Three clustered Sp1 sites are required for efficient transcription of the TATA-less promoter of the gene for insulin-like growth factor binding protein-2 from the rat. Journal of Biological Chemistry. 268:24892-24901. 1993
- Analysis and pharmacokinetics of cimaterol in growing Holstein steers. Journal of Animal Science. 70:3812-3819. 1992
- Effect of prepartum energy, body condition and sodium bicarbonate on health and metabolites of Holstein cows in early lactation. Journal of Dairy Science. 70:2280-2290. 1987
- The effect of prepartum energy, body condition and sodium bicarbonate on production in early lactation. Journal of Dairy Science. 69:2636-2647. 1986
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article
- You need to know about leptin 2003
- Growth hormone, a step toward the year 2000. Holstein J.. 109. 1986
- The fat cow syndrome and its complication. Holstein J.. 117. 1985
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chapter
- Update on endocrine mechanisms regulating nutrient partitioning in growing animals. Energy and Protein Metabolism and Nutrition. 353-361. 2010
- Roles of growth hormone and leptin in the periparturient dairy cow. Wageningen Academic Publishers. 327-346. 2006
- Molecular biology of the insulin-like growth factor binding proteins. The IGF System: Molecular Biology, Physiology and Clinical Applications. 111-139. 1999
- Nutritional regulation of gene expression and animal development. Recent Advances in Animal Nutrition in Australia. 167-178. 1999
- Regulation of the ALS gene expression by growth hormone. Molecular Mechanisms to Regulate the Activities of Insulin-like Growth Factors. 49-56. 1998
- Transcriptional regulation of the rat IGFBP-1 and IGFBP-2 genes. The Insulin-Like Growth Factors and their Regulatory Proteins. 163-174. 1994
- Regulation of nutrient partitioning: homeostasis, homeorhesis, and exogenous somatotropin. Proceedings of the 7th International Conference on Production Disease in Farm Animals. 306-323. 1989
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conference paper
- Plasma angiopoietin-like protein 4 concentration is decreased by energy restriction in lactating dairy cattle. Ruminant physiology. Digestion, metabolism and effects of nutrition on reproduction and welfare. 2009
- Consequences of high milk allowance before weaning on metabolic hormones in plasma, muscle tissue expression of growth factors, weight of muscles, and composition of mammary gland at 90 kg BW or at 12 weeks of age. 6th International Conference on Farm Animal Endocrinology, Roanoke, VA. 2008
- Effect of chronic growth hormone and hyperinsulinemic euglycemia on endogenous glucose production and utilization in periparturient dairy cows. The Journal of the Federation of American Societies for Experimental Biology (FASEB). 2008
- Effect of the prolactin-release inhibitor Quinagolide on dairy cows. American Dairy Science Association Annual Meeting. 2008
- Effects of chronic growth hormone administration on growth and the circulating IGF system to male and female hypomorphic STAT5 mice. 90th Annual Meeting of The Endocrine Society, San Francisco, CA. 2008
- Effects of prepartum 2,4-thiazolidinedione on plasma leptin and insulin sensitivity in transition dairy cows. American Dairy Science Association Annual Meeting. 2008
- Expression of gene for melanin concentrating hormone, but not the gene for orexin is increased with intrauterine growth restriction (IIUGR) of sheep fetuses. 50th Annual Meeting of The Endocrine Society of Australia, Melbourne, Australia. 2008
- Impaired mammary gland development in obese mice lacking leptin dependent STAT3 signaling. 90th Annual Meeting of The Endocrine Society, San Francisco, CA. 2008
- Mammary expression of activating transcription factor 4 (ATF4) and tribbles homolog 3 (TRB3) is up-regulated during CLA-induced inhibition of milk fat synthesis in the dairy cow. The Journal of the Federation of American Societies for Experimental Biology (FASEB). 2008
- Mammary expression of activating transcription factor 4 (ATF4) and tribbles homolog 3 (TRB3) is up-regulated during CLA-induced inhibition of milk fat synthesis in the dairy cow. The Journal of the Federation of American Societies for Experimental Biology (FASEB). 2008
- SREBP1 and Spot14 are acutely down-regulated in mammary tissue during abomasal infusion of trans-10, cis-12 conjugated linoleic acid (CLA) in the dairy cow. Journal of Dairy Science. 567. 2008
- Trans-10, cis-12 conjugated linoleic acid (CLA)induces a dose-dependent reduction in milk fat synthesis in C57BL6J mice. Journal of Dairy Science. 567. 2008
- Ontogenic expression of microRNA in bovine mammary gland. ADSA/ASAS/PS Meetings. 2007
- Recent advances in the regulation of milk fat synthesis. 58th Annual meeting of the European Association for Animal Production (EAAP). 2007
- Role of central leptin and melanocortins in regulating insulin-mediated glucose metabolism in pheripheral tissues of underfed ruminants. USDA-NRI Animal Growth and Nutrient Utilization PD Meeting. 2007
- A mammary gland biologist’s perspective on functional genomics. 8th World Congress on Genetics Applied to Livestock Production. 2006
- Advancements and future challenges in understanding mammary gland function. ASAS/ADSA Joint Meeting. 2006
- Effect of ovarian status and estrogen on leptin and leptin receptor expression in prepubertal dairy heifers. 88th Annual Meeting of the Endocrine Society. 2006
- Effects of chronic growth hormone administration on growth and the circulating IGF system in null ALS mice. 88th Annual Meeting of the Endocrine Society. 2006
- Effects of chronic infusion of the -melanocyte-stimulating hormone analog, MT-I, and AGRP on food intake in mature sheep. 88th Annual Meeting of the Endocrine Society. 2006
- Isolation of the cDNA encoding the acid-labile subunit (ALS) of the 150 kDa IGF-binding protein complex in cattle and ALS regulation during the transition from pregnancy to lactation. 88th Annual Meeting of the Endocrine Society. 2006
- Regulation of gene expression in the bovine mammary gland by ovarian steroids. ASAS/ADSA Joint Meeting. 2006
- Regulation of hepatic leptin receptor expression in periparturient dairy cows. ASAS/ADSA Joint Meeting. 2006
- Effect of ovariectomy and estradiol administration on bovine skeletal muscle insulin-like growth factor I (IGF-I) and -adrenergic receptor (-AR) messenger RNA (mRNA) abundance. ASAS/ADSA Joint Meeting. 2005
- Effects of modified calf growth on mammary development, endocrine physiology and performance. ASAS/ADSA Joint Meeting. 2005
- Endocrine changes and tissue accretion rates in prepubertal heifers fed at moderate or high feeding levels from 90 to 240 kg BW. 5th International Conference on Farm Animal Endocrinology. 2005
- Implications of a dysfunctional somatotropic axis during the transition period of dairy cattle. Southwest Nutrition Conference. 197-208. 2005
- Leptin does not act directly on mammary epithelial cells in prepubertal dairy heifers. 87th Annual Meeting of the Endocrine Society. 2005
- Leptin gene polymorphisms and selection for milk yield in Holstein cows. ASAS/ADSA Joint Meeting. 2005
- Propionate does not stimulate leptin secretion in lactating dairy cows. Experimental Biology 2005 meeting. 2005
- Triple gene inactivation of liver igf-1, the acid labile subunit and the IGFBP-3 leads to undetectable levels of serum IGF-1. 87th Annual Meeting of the Endocrine Society. 2005
- Developmental and nutritional regulation of steroid receptor mRNA expression and epithelial cell proliferation in the prepubertal bovine mammary gland. J. Anim. Sci. 82(1):240. 2004
- Reduction of the growth hormone receptor in liver and adipose tissue of early lactating dairy cows. 86th annual meeting of The Endocrine Society. 2004
- What is leptin and what role might it pay in ruminant metabolism?. Cornell Nutrition Conference. 72-80. 2000
- What is leptin and what role might it play in ruminant metabolism? . Proceedings of Cornell Nutrition Conference. 72-80. 2000
- Growth hormone stimulation of the acid labile subunit (ALS) gene expression in rat liver cells is mediated by Stat5a and –5b isoforms. Proceedings, 17th Annual Congress of Biochemistry and Molecular Biology and Annual Meeting for the Biochemistry and Molecular Biology, San Francisco, CA. 1997
- bST: long term effects. Dairy Cow Symposium, CPAQ. 103-132. 1995
- Manipulation of milk production with bovine somatotropin: definition, biological concepts and mechanisms of action. Proc. 13th Annual Meeting Can. Assoc. Anim. Breeders. 88-94. 1990
- Mechanisms of action of bovine somatotropin during lactation: target tissues and whole animal integration. Proceedings of the 1st Laval Nutrition Conference. 28-38. 1990
- Relationship of prepartum energy intake and body composition with postpartum health and performance of dairy cows. Proc. Guelph Nutr. Conf.. 119-126. 1985
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document part
- Thyroid hormone responsive spot 14 null mice are acutely responsive to trans-10, cis-12 conjugated linoleic acid (CLA) in the mammary gland. 416. 2012
- Effect of fish oil supplementation on lipogenic gene expression in mammary gland and liver in mice 2011
- The role of central leptin signaling in regulating peripheral metabolic adaptations in the sheep. 82. 2011
- Effects of birth weight and dietary caloric density on growth, voluntary intake and body composition of newborn lambs. 215. 2010
- An intact SREBP pathway is essential for the trans-10, cis-12 CLA-induced inhibition of de novo of fatty acid synthesis in the murine lactating mammary gland. 50-51. 2009
- Conjugated linoleic acid effects on adiposity are independent of spot 14 expression. 240. 2009
- Expression of thyroid hormone responsive spot 14 and a homologous protein (MIG12) are dynamically regulated in adipose tissue of dairy cows during modification of energy balance. 285. 2009
- Fibroblast growth factor 21 (FGF21) expression is increased in hepatic tissue of feed-restricted cows during the transition from pregnancy to lactation. 555. 2009
- Mammary expression of activating transcription factor 4 (ATF) and tribbles homolog 3 (TRB3) is up-regulated during CLA-induced inhibition of milk fat synthesis in the dairy cow. 327. 2009
- Regulation of adiponectin during the transition from pregnancy to lactation in dairy cattle 2008
- Effect of continuous leptin infusion on whole body energetics, metabolism and hormone secretion in the energy deficient, early lactating cow 2007
- Ontogenic expression of microRNA in bovine mammary gland. 414. 2007
- Advancements and future challenges in understanding mammary gland function. 409. 2006
- Regulation of gene expression in the bovine mammary gland by ovarian steroids. 426. 2006
- Regulation of hepatic leptin receptor expression in periparturient dairy cows. 288. 2006
- Effect of ovariectomy and estradiol administration on bovine muscle insulin-like growth factor-I (IGF-I) and β-adrenergic receptor (βAR) messenger RNA (mRNA) abundance. 283. 2005
- Developmental and nutritional regulation of steroid receptor mRNA expression and epithelial cell proliferation in the prepubertal bovine mammary gland. 240. 2004
- Changes in plasma leptin from birth to puberty in dairy cattle. 308. 2003
- Nutritional modulation of hepatic growth hormone responsiveness in late-lactating dairy cows. Changes in plasma leptin from birth to puberty in dairy cattle. 297. 2003
- Regional expression of IGF-I and estrogen receptor-alpha within prepubertal bovine mammary parenchyma and fat pad. Changes in plasma leptin from birth to puberty in dairy cattle. 301. 2003
- Analysis of the spatial, hormonal and developmental regulation of the estrogen receptor α gene in cattle. 338. 2002
- Effect of insulin on leptin production in the periparturient dairy cow. 399. 2002
- Effect of insulin on the GH-IGF-I axis in the periparturient dairy cow. 195. 2002
- Role of insulin and growth hormone in regulating the concentration of plasma leptin in lactating dairy cows. 195-196. 2002
- Effect of conjugated linoleic acids (CLA) on parameters of adipose tissue metabolism in the lactating dairy cow. 222. 2000
- Effect of energy balance on the concentration of plasma leptin in early lactating dairy cows. 19. 2000
- Nutritional regulation of circulating leptin in growing lambs is influenced by sex. 18-19. 2000
- Regulation of leptin mRNA and plasma leptin during fetal life and the transition from pregnancy to lactation in ruminants. 178. 2000
- Effect of bovine somatotropin on glucose metabolism in steers 1989
- Increased response of adipose tissue to lipolytic stimuli in bovine somatotropin treated growing cattle. 216. 1989
- Regulation of nutrient partitioning: homeostasis, homeorhesis and exogenous somatotropin. 60. 1989
- Muscle protein synthesis and whole-body N balance in fed and underfed steers 1988
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report
- Mecanismes d'action de la somatotropine chez la vache laitiere: effets sur le metabolisme des tissus et integration au niveau de l'animal 1990
- Regulation of nutrient partitioning: homeostasis, homeorhesis and exogenous somatotropin 1989
speaker at Cornell event
Teaching
teaching overview
- I teach Biology of Lactation ( AnSc 3410). This is a capstone course in physiology directed to both students interested in biomedical, and those interested in applied careers. I contribute 35% of the lectures in the course entitled Mechanisms of Growth and Development (AnSc 3920). This is a course directed to students primarily interested in recent advances in growth biology. I teach Seminar in Animal Metabolism (AnSc 6220). This class covers the latest discoveries in metabolism and seeks to broaden the scientific currency of graduate students engaged in nutritional and metabolic research.
teaching activities
- ANSC-3410: Biology of the Mammary Gland in Health and Disease - Spring 2013
- ANSC-3920: Mechanisms of Animal Growth and Development - Spring 2013
- ANSC-7900: Graduate-Level Thesis Research - Spring 2013
- ANSC-8900: Master's Level Thesis Research - Spring 2013
- ANSC-9900: Doctoral-Level Thesis Research - Spring 2013
- BIOAP-3410: Biology of the Mammary Gland in Health and Disease - Spring 2013
- ANSC-7900: Graduate-Level Thesis Research - Fall 2012
- ANSC-8900: Master's Level Thesis Research - Fall 2012
- ANSC-9900: Doctoral-Level Thesis Research - Fall 2012
- ANSC-3410: Biology of the Mammary Gland in Health and Disease - Spring 2012
- ANSC-3920: Mechanisms of Animal Growth and Development - Spring 2012
- ANSC-7900: Graduate-Level Thesis Research - Spring 2012
- ANSC-8900: Master's Level Thesis Research - Spring 2012
- ANSC-9900: Doctoral-Level Thesis Research - Spring 2012
- BIOAP-3410: Biology of the Mammary Gland in Health and Disease - Spring 2012
- ANSC-7900: Graduate-Level Thesis Research - Fall 2011
- ANSC-8900: Master's-Level Thesis Research - Fall 2011
- ANSC-9900: Doctoral-Level Thesis Research - Fall 2011
Service
service to the profession
- AI-SPER-0203DF692AB000108EA Member 2008 -
- American Society of Nutritional Sciences Member 1995 -
- American Association for the Advancement of Science Member 1994 -
- American Society of Animal Science Member 1991 -
- Endocrine Society Member 1990 -
- University of Illinois Evaluation of tenure and promotion - 2010
- Virginia Tech University Evaluation of tenure and promotion - 2010
- King Addulaziz City for Science and Technology (Saudi Arabia) Research Review Panel 2009
- Northeast ASAS ADSA Award Committee Member - 2008
- University of Melbourne External reviewer - 2008
- McGill University Thesis evaluation - 2006
- Penn. State University, Department of Dairy and Animal Science External Evaluator of faculty promotion package - 2005
- Monash University Ph. D. thesis evaluation - 2004
- University of Sydney Kolling Institute Ph. D. thesis evaluation - 2001
reviewer or editor for
- Affinito-Stewart Faculty Grant Program
- Agence Nationale de Recherche
- BARD (US-Israel Binational Funding Agency)
- Binational Agricultural Research and Development Fund
- Biochemica et Biophysica Acta
- British Journal of Nutrition
- Canadian Foundation for Innovation
- Dairy Farmers of Canada
- Domestic Animal Endocrinology
- Domestic Animal Endocrinology
- Endocrinology
- Endocrinology
- Endocrinology
- Foundation for Research, Science and Technology
- Hatch Proposal Evaluation
- Hatch Proposal Evaluation
- International Congress on Animal Reproduction
- Journal of Animal Sciecne
- Journal of Animal Science
- Journal of Cellular Physiology
- Journal of Clinical Physiology and Metabolism
- Journal of Dairy Science
- King Abdulaziz City of Science and Technology (KACST-Saudi Arabia)
- Marsden Fund, The Royal Society of New Zealand
- McGill-Weizmann Joint Research program
- NIH, National Institute of General Medical Sciences
- National Research Initiative Grants Program
- National Science Foundation
- National Sciences and Engineering Research Council of Canada
- Natural Sciences and Engineering Research Council of Canada
- Proposal for funding by King Abdulaziz City for Science and Technology (KACST)
- US-Israel Binational Science Foundation
- USDA National Program 101 Panel 5-Nutritional Physiology: Ruminant Dairy Peer Review Panel
- Welcome Trust
Background
education and training
- Ph.D. in Animal Science, Cornell University 1991
- University of Guelph 1984
- B.S. in Animal Science, Universite Laval 1980
awards and honors
- Young Scientist Award, NE Section, 2000
- Postdoctoral Scholarship (Declined), 1991
- Fogarty Fellowship (Visiting Fellow), 1991
- Postdoctoral Fellowship, 1990
- Research Fellowship in Animal Sciences, 1987
- Scholarship, 1986
- Ralston Purina Fellowship in Dairy Science (Declined), 1984
- Mary Edmund Williams Fellowship, 1983
- Postgraduate Scholarship, 1982
Other
research keyword
- Hormone
- cattle
- growth
- growth hormone
- insulin-like growth factor
- lactation
- leptin
- metabolism
- mouse
- sheep