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Co-Investigators
Chang, Yung-Fu
Cornell Faculty Member
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Positions
- Professor, Population Medicine and Diagnostic Sciences (VTPMD), College of Veterinary Medicine
- Academic Director, Animal Health Diagnostic Center, College of Veterinary Medicine - 2012
- Affiliations
- Extension
- Research
- Publications
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Affiliations
other Cornell affiliations
Extension
has primary specialization area
Research
research overview
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- Molecular biology of infectious disease
- DNA and recombinant subunit vaccine development
- Molecular basis of bacterial pathogenesis
- Immunopathology of infectious disease
- Molecular diagnosis of infectious diseases
- Host defense mechanisms
- Comparative genomics and proteomics
My research focuses on both basic and applied aspects. My research interest is to understand the mechanisms of infection and concurrently develop an effective vaccine to prevent the infection of the pathogens such as M. avium subsp. paratubercuosis, Leptospira and Salmonella.
principal investigator on
- A NOVEL PNAG-TETANUS TOXOID CONJUGATA VACCINE AGAINST ACTINOBACCILLUS PLEUROPEUMONIAE IN PIGLETS awarded by ALOPEXX PHARMACEUTICALS, LLC 2013
- COMPARATIVE TRANSCRIPTOME ANALYSIS OF CLOSTRIDIUM DIFFICLE STRAINS awarded by NATL INST OF ALLERGY & INFECTIOUS DISEASE NIH 2010 - 2013
- CONSTRUCTION OF M. AVIUM SUBSP. PARATUBERCULOSIS MUTANTSAS VACCINE CANDIDATE awarded by AGRICULTURE RESEARCH SERVICE USDA (USDA-ARS) 2009 - 2012
- DEVELOPMENT OF A VACCINE DELIVERY SYSTEM AGAINST BOVINE LEPTOSPIROSIS awarded by AGRICULTURE RESEARCH SERVICE USDA (USDA-ARS) 2009 - 2012
- DEVELOPMENT OF AN EQUINE LEPTOSPIRAL CHALLENGE MODEL: ADDENDUM RESEARCH PROTOCOL - B-6 awarded by PFIZER, INCORPORATED 2011 - 2012
- PROTECTIVE EFFICACY OF GENETICALLY ENGINEERED SALMONELLA STRAINS AGAINST MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS awarded by NATIONAL INSTITUTE OF FOOD AND AGRICULTURE-USDA 2009 - 2013
co-principal investigator on
- FUNCTIONAL ANALYSIS OF CROHN'S ASSOCIATED ADHERENT AND INVASIVE E. COLI awarded by CROHN'S & COLITIS FDN OF AMERICA 2011 - 2013
- INVESTIGATING THE RISK ASSOCIATED WITH FOODBORNE PATHOGENS AND THE POTENTIAL RELATION TO INFLAMMATORY BOWEL DISEASE IN QATAR awarded by QATAR FOUNDATION 2009 - 2013
- SERUM ELISA, MILK ELISA, AND ORGANISM DETECTION TEST LABORATORIES awarded by NATIONAL INSTITUTE OF FOOD AND AGRICULTURE-USDA 2011 - 2012
Publications
selected publications listing
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- Lin Y.P., A. Greenwood, L. K. Nickolson, Y. Sharma, S. P.McDonough, and Y. F. Chang. 2009. Fibronectin binds to and induces conformational change in a disordered region of Leptospiral immunoglobulin-like protein B. J. Biol. Chem. 284:23547-23557.
- Lin Y.P., D.W. Lee, S. P. McDonough, L. K. Nicholson, Y. Sharma, and Y. F. Chang.2009. Repeated domains of leptospira immunoglobulin-like proteins interact with elastin and tropoelastin. J. Biol. Chem. 284:19380-19391.
- Janvilisri T., J. Scaria, A. Thompson, A. Nicholson, B. Limbargo, L. G. Arroyo, J. G. Songer, Y. T. Grohn, and Y. F. Chang. 2009. Microarray identification of Clostridium difficile core components and divergent regions associated with host origin. J. Bacteriol. 191:3881-3891.
- Yan, W., S. M. Faisal, S. P. McDonough, T. J. Divers, S. C. Barr, M. J. Pan, C. F. Chang and Y.F. Chang. 2009. Recombinant Leptospira Immunoglobulin-Like Protein B (rLigB) protects hamsters against lethal Leptospira interrogans infection. Microbes Infect.11:230-237.
- Faisal, S.M., W. Yan, S. P. McDonough, and Y. F. Chang 2009. Leptospira immunoglobulin-like protein A variable region (LigAvar) incorporated in Liposomes and PLGA-Microspheres produces a robust immune response correlating to protective immunity. Vaccine 27:378-387.
- Kathaperumal, K,, V. Kumanan, S. McDonough, L. H. Chen, S. U. Park, M. A. Moreira, B. Akey, J. Huntley, C. F. Chang, and Y. F. Chang 2009. Evaluation of immune responses and protective efficacy in a goat model following immunization with a coctail of recombinant antigens and a polyprotein of Mycobacterium avium subsp. paratuberculosis. Vaccine 27:123-135.
- Scaria, J., A. Sreedharan, and Y. F. Chang. 2008. Microbial Diagnostic Array Workstation (MDAW): A web server for diagnostic array data storage, sharing and analysis. Source Code Biol. Med. 3:14-18.
- Lin, Y.P. R. Raman, Y. Sharma, and Y. F. Chang. 2008. Calcium binds to Leptospiral immunoglobulin-like protein, LigB and modulates fibronectin-binding. J. Biol. Chem. 283(12): 25140-25149.
- Park, S.U., K. Kathaperumal, S. McDonough, B. Akey, J. Huntley, J. P. Bannantine and Y.F. Chang. 2008. Immunization with a DNA vaccine cocktail induces a Th1 response and protects mice against Mycobacterium avium subsp. paratuberculosis. Vaccine. 26:4329-4337.
- Scaria, S., P. U. M. Palaniappan, D. Chiu, J.A. Phan, L. Ponnala, P. McDonough, Y. T. Grohn, S. Porwollik, M. McClelland, C.S. Chiou, C. Chu and Y. F. Chang. 2008. Microarray for molecular typing of Salmonella enterica serovars. Mol. Cell. Probes 22:238-243.
- Lin, Y.P. and Y. F. Chang. 2008. The C-terminal variable domain of LigB from Leptospira mediates binding to fibronectin. J. Vet. Sci. 9:133-144.
- Kathaperumal, K., S. U. Park, S. P. McDonough, S. Stehman, B. Akey, J. Huntley, S. Wong, L. H. Chen, C.-F. Chang and Y. F. Chang. 2008. Vaccination with recombinant Mycobacterium avium subsp. paratuberculosis proteins induces differential immune responses and protects calves against infection by oral challenge. Vaccine, 26:1652-1663.
- Chen, L. H., K. Kathaperumal, C. J. Huang, S. P. McDonough, S. Stehman, B. Akey, J. Huntley, C.F. Chang and Y. F. Chang. 2008. Immune responses in mice to Mycobacterium avium subsp. paratuberculosis following vaccination with a novel 74F recombinant polyprotien. Vaccine 26:1253-1262.
- Faisal, S.M., W. Yan, C. S. Chen, R. U.M. Palaniappan, S. P. McDonough, and Y. F. Chang. 2008. Evaluation of protective immunity of Leptospira immunoglobulin like protein A (LigA) DNA vaccine against challenge in hamsters. Vaccine, 26:277-287.
- Yu, C.Y., S. J. chou, C. M. Yeh, M.R. Chao, K. C. Huang, Y. F. Chang, C. S. Chiou, F. X. Weill, C. H. Chiu, C. H. Chu, and C. S. Chu. 2007. Prevalence and characterization of multidrug-resistant (ACSSuT) Salmonella enterica serovar Typhimurium isolated from our Gosling’s farms and a hatchery farm. J. Clin. Microbiol. 46:522-526.
- Chang, Y.F., C. S. Chen, R. U.M. Palaniappan, S. P. McDonough, W. Yang, M. J. Pan, and C. F. Chang. 2007. Immunogenicity and protection of the recombinant leptospiral immunogenic proteins as vaccine candidates. Vaccine 25: 8190-8197.
- Lin, Y.P. and Y. F. Chang. 2007. A domain of the Leptospira LigB contributes to high binding of fibronectin. Biochem. Biophy. Res. Comm. 362:443-448.
- Palaniappan, R. U., S. Ramanujam and Y. F. Chang. 2007. Leptospirosis: Pathogenesis, Immunity, and Diagnosis. Current Opinion Infect. Dis. 20:284-292.
- Palaniappan, R. U., Y. Zhang, D. Chiu, A. Torres, C. DebRoy, T. S. Whittam and Y. F. Chang. 2006. Differentiation of Escherichia coli pathotypes by oligonucleotide spotted array. J. Clin. Microbiol. 44:1495-1501.
- Raghavan, P. U. M., S. P. McDonough, T. J. Divers, C. S. Chen, M.J. Pan, M. Matsumoto and Y. F. Chang. 2006. Immunoprotection of recombinant leptospiral immunoglobulin like A protein (LigA) against Leptospira interrogans serovar Pomona infection. Infect. Immun. 74:1745-1750.
- Ku, Y.W., S. P. McDonough, R.U.M. Palaniappan, C. F. Chang, Y. F. Chang. 2005. Identification and characterization of in vivo attenuated mutants of Salmonella enterica serovar Choleraesuis using signature-tagged mutagenesis in a pig infection model. Infect. Immun. 73:8194-8203.
- Shin, S.J., C.F. Chang, C. C. Chang, S. P. McDonough, B. Thompson, H.S. Yoo, and Y. F. Chang. 2005. In vitro cellular immune response to recombinant antigens of Mycobacterium avium subsp. paratuberculosis. Infect. Immun. 73:5074-5085.
- Hsieh, W.J., Y.F. Chang, C. S. Chen, and M. J. Pan. 2005. Omp52 is a growth-phase-regulated outer membrane protein of Leptospira santarosai serovar Shermani. FEMS Microbiol. Let. 243:339-345.
- Palaniappan, R. U., Y. F. Chang, C. F. Chang, M. J. Pan, C. W. Yang, P. Harpending, S. P. McDonough, E. Dubovi, J. Qu, B. Roe and T. Divers. 2005. Evaluation of lig-based conventional and real time PCR for the detection of pathogenic leptospires. Mol. and Cell. Probes. 19:111-117.
- Wang, Z., Z. Yuan, M. Matsumoto, U. R. Hengge and Y. F. Chang. 2005. Immune responses with DNA vaccines encoded different gene fragments of severe acute respiratory syndrome coronavirus in BALB/c mice. BioChem. BioPhy. Res. Com. 327:130-135.
featured in archived article
Background
education and training
- Ph.D. in Microbiology/Immunology, Texas A&M University 1984
- M.S. in Immunology/Pathology, University of Idaho 1981
- D.V.M., National Pingtung Institute of Agriculture 1974