• Understanding interactions among proteins, electrons, and photons
• How metalloenzymes stabilize transient intermediates during catalysis
• How protein structure controls long-range electron transfer
• How photo and redox processes are used in biological information transfer
• Combine genetic and chemical manipulation of proteins, atomic-resolution structure determination, and novel photochemically triggered experiments in single crystals
• Understanding How Structure Controls Electron Transfer and Activated States in Metalloenzymes
• Bacterial Nitric Oxide Synthases:
• Light and Redox Sensing
• Bacterial Chemotaxis
  

Vaidya AT, Chen CH, Dunlap JC, Loros JJ, Crane BR. Structure of a Light-Activated LOV Protein Dimer That Regulates Transcription. Sci Signal. 2011, 4

Paul K, Gonzalez-Bonet G, Bilwes AM, Crane BR, Blair D. Architecture of the flagellar rotor. EMBO J. 2011, 30, 2962-71.

Airola MV, Watts KJ, Bilwes AM, Crane BR. Structure of concatenated HAMP domains provides a mechanism for signal transduction. Structure 2010, 18, 436-48.

Bhatnagar J, Borbat PP, Pollard AM, Bilwes AM, Freed JH, Crane BR. Structure of the ternary complex formed by a chemotaxis receptor signaling domain, the CheA histidine kinase, and the coupling protein CheW as determined by pulsed dipolar ESR spectroscopy. Biochemistry 2010, 49, 3824-41.

Patel BA, Moreau M, Widom J, Chen H, Yin L, Hua Y, Crane BR. Endogenous nitric oxide regulates the recovery of the radiation-resistant bacterium Deinococcus radiodurans from exposure to UV light. Proc Natl Acad Sci U S A 2009, 106, 18183-8.

Zoltowski BD, Vaccaro B, Crane BR. Mechanism-based tuning of a LOV domain photoreceptor. Nat Chem Biol. 2009, 5, 827-34.

Zoltowski, B.D., Schwerdtfeger, C., Widom, J. Loros, J.J., Bilwes, A. M., Dunlap, J., C. & Crane, B.R. Conformational switching in the fungal light sensor Vivid. Science, 2007, 316 1054-1057.

Park, S. Y., Borbat, P. P., Gonzalez-Bonet, G., Bhatnagar, J., Freed, J. H., Bilwes, A. M. & Crane, B. R. Reconstruction of the chemotaxis receptor:kinase assembly Nat. Struct. Mol. Biol., 2006, 13, 400-407.

Chao, X., Muff, T., Park, S., Zhang, S., Pollard, A. M., Ordal, G., Bilwes, A. M. & Crane, B.R. A receptor-modifying deamidase in complex with a signaling phosphatase reveals a mechanism of reciprocal regulation. Cell, 2006, 124, 561-571.

Kang, S. A. & Crane, B.R. Effects of interface mutations on association modes and electron transfer rates between proteins. Proc. Natl. Acad. Sci. USA, 2005, 102, 15465-15470.

Kers, J. A., Wach, M. J., Krasnoff, S. B., Widom, J., Cameron, K. D., Bukhalid, R. A., Gibson, D. M., Crane, B. R. & Loria, R. Nitration of a peptide phytotoxin by bacterial nitric oxide synthase. Nature, 2004, 429, 79-82.

• Searle Scholar
• NSF CAREER Award
• Camille and Henry Dreyfus Young Faculty Award
• Research Innovation Award, Research Corporation