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Map Of Science
Lei, Xingen
Cornell Faculty Member
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Positions
Research Areas
- agricultural biotechnology
- animal science
- biochemistry
- biotechnology
- environmental sciences
- food science
- genomics
- international agriculture
- international development
- molecular biology
- nutrient management
- nutritional sciences
- toxicology
- value-added agriculture
- Affiliations
- Research
- Publications
- Teaching
- Service
- Background
- Other
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Affiliations
member of
- David R. Atkinson Center for a Sustainable Future (ACSF) Faculty Fellow
Research
research overview
- 1. Functional genomics of mineral-dependent enzymes (Se-GPX1 and Cu,Zn-SOD1) in antioxidation, cell death, signal transduction, glucose metabolism (insulin sensitivity), diabetes, obesity, and bone integrity in gene-knockout mice, pigs, and primary cells. 2. Overexpression and protein engineering of phytases and proteases to improve mineral (P, Ca, Fe, and Zn) and protein nutrition in animals and humans, and to protect environmental pollution of animal waste. 3. Pigs as a model to fight against global micro-nutrient deficiencies in humans. 4. Developing a new generation of animal feed protein supplements from algal biofuel production.
research activities
- Development of novel feather-degrading protease complex for environmental, nutritional, and industrial applications
- Algal Bioenergy Production
- Biofortifying staple crops to prevent micronutrient deficiencies in humans
- Developing a new generation of feed protein supplements from algal biofuel production
- Development of novel phytase to reduce phosphorus pollution of animal waste
- Harvest Plus: Breeding crops for better nutrition
- The role of antioxidant enzymes on diabetes
principal investigator on
area(s) of concentration/expertise
- Agricultural and Environmental Bioprocessing Engineering
- Agriculture Development, Food Systems, Community Development
- Animal Science International
- Animal Science, Animal nutrition
- Antioxidants, Functional Foods, Food Analysis, Nutritional Quality & Biochem of Fruits & Veg
- Biochemistry
- Biotechnology and intellectual property rights
- Food Science
- International Agriculture/Biotechnology
- Molecular & Structural Biology
- Molecular Nutrition of Minerals
- Nutrient Management - Agric Systems
- Nutrition
- Nutritional Biochemistry
- Obesity, Nutrition and Behavior
- molecular nutrition
keywords
- algal biomass
- biofuel production
- mineral, selenium, copper, iron, phytase, protease, biotechnology, environment, diabetes, obesity, biofortification, protein engineering, molecular nutrition
submitted impact statement
- Using pigs as a model to fight global deficiencies of iron, zinc, and vitamin A in humans
- Metabolic roles of selenium-dependent enzymes in body antioxidation and diabetes
- Functional genomics of antioxidant enzymes in oxidative stress and chronic diseases
- Development of effective phytase to reduce phosphorus pollution of animal waste
Publications
individual publications
-
academic article
- Gene expression of endoplasmic reticulum resident selenoproteins correlates with apoptosis in various muscles of se-deficient chicks.. Journal of Nutrition. 2013
- Selenoprotein W serves as an antioxidant in chicken myoblasts.. Biochimica et Biophysica Acta. 1830:3112-3120. 2013
- A high-selenium diet induced insulin resistance in gestating rats and their offspring.. Free Radic. Biol. Med.. 52:1335-1342. 2012
- Dietary selenium deficiency partially rescues type 2 diabetes-like phenotypes of glutathione peroxidase-1-overexpressing male mice.. Journal of Nutrition. 142:1975-1982. 2012
- Invited Review: New views of selenium, selenoproteins, and their roles in diabetes and dyslipidemia.. Chin. Bull. Life Sci.. 24:881-891. 2012
- Knockout of SOD1 altered murine hepatic glycolysis, gluconeogenesis, and lipogenesis.. Free Radic. Biol. Med.. 53:1689-1696. 2012
- Phytase: a new life for an “old” enzyme.. Annual Review of Animal Biosciences. 2012
- Prolonged dietary selenium deficiency or excess does not globally affect selenoprotein gene expression and/or protein production in various tissues of pigs.. Journal of Nutrition. 142:1410-1416. 2012
- Haploid insufficiency of suppressor enhancer Lin12 1 like (SEL1L) predisposes mice to high fat diet-induced hyperglycemia. Journal of Biological Chemistry. 286:22275-22282. 2011
- Haploid insufficiency of suppressor enhancer Lin12 1-like (SEL1L) protein predisposes mice to high fat diet-inducedhyperglycemia. Journal of Biological Chemistry. 286:22275-82. 2011
- Impacts of dietary selenium deficiency on metabolic phenotypes of diet-restricted gpx1-overexpressing mice. Antioxidants & Redox Signaling. 14:383-90. 2010
- Knockouts of SOD1 and GPX1 exert different impacts on murine islet function and pancreatic integrity. Antioxidants & Redox Signaling. 14:391-401. 2010
- Lipopolysaccharide-induced hepatic oxidative injury is not potentiated by knockout of GPX1 and SOD1 in mice. Biochemical and Biophysical Research Communications. 404:559-63. 2010
- Molecular characterization and NF-kB-regulated transcription of selenoprotein S from the Bama mini-pig. Molecular biology reports. . 2010
- Nicotianamine, a novel promoter of iron absorption from rice grain. PLoS One. 5. 2010
- Site-directed mutagenesis of disulfide bridges in Aspergillus niger NRRL 3135 phytase (PhyA), their expression in Pichia pastoris and catalytic characterization. Applied Microbiology and Biotechnology. 87:1367-72. 2010
- Supplemental dietary inulin of variable chain lengths alters intestinal bacterial populations in young pigs. Journal of Nutrition. 140:2158-2161. 2010
- Two tales of antioxidant enzymes on β cells and diabetes. Antioxidants & Redox Signaling. 14:489-503. 2010
- Dietary Inulin Supplementation Does Not Promote Colonic Iron Absorption in a Porcine Mode. Journal of Agricultural and Food Chemistry. 57:5250-5256. 2009
- Biofortified black beans in a maize and bean diet provide more bioavailable iron to piglets than standard black beans. Journal of Nutrition. 139:305-309. 2009
- Comparative impacts of knockouts of two antioxidant enzymes on acetaminophen-induced hepatotoxicity in mice. Experimental Biology & Medicine. 234:1477-83. 2009
- Impact of assay conditions on activity estimate and kinetics comparison of Aspergillus niger PhyA and Escherichia coli AppA2 phytases. Journal of Agricultural and Food Chemistry. 57:5315-20. 2009
- Iron and zinc bioavailabilities to pigs from red and white beans (Phaseolus vulgaris L.) are similar. Journal of Agricultural and Food Chemistry. 57:3134-40. 2009
- Selenoprotein gene expression in thyroid and pituitary of young pigs is not affected by dietary Se deficiency or excess. Journal of Nutrition. 139:1061-6. 2009
- Supplemental dietary inulin suppresses expression of iron-related inflammation genes in young pigs. Journal of Nutrition. 139:2018-23. 2009
- Assembly of mutations for the improved thermostability of Escherichia coli AppA2 phytase. Applied Microbiology and Biotechnology. 79:751-758. 2008
- Copper deficiency induces a connective tissue disorder state in a porcine native abdominal aortic aneurysm model. FASEB Journal. 22. 2008
- Cumulative Improvements of Thermostability and pH-activity Profile of Aspergillus niger PhyA Phytase by Site-directed Mutagenesis. Applied Microbiology and Biotechnology. 77:1033-1040. 2008
- Dietary inulin affects the expression of intestinal enterocyte iron transporters, receptors, and storage protein and alters the microbiota in the pig intestine. British Journal of Nutrition. 99:472-480. 2008
- Differential expression of 15 selenoprotein genes in various tissues of pigs. Journal of Animal Science. 86. 2008
- Effects of dietary selenium on expression of selenoproteins and activity of antioxidant enzymes in endocrine tissues of growing male pigs. Journal of Animal Science. 86:198. 2008
- Effects of three types of inulin on dietary iron bioavailability and site of their disappearance in the digestive tract of young pigs. FASEB Journal. 22. 2008
- Enhancing thermostability of Escherichia coli phytase AppA2 by error-prone PCR. Applied Microbiology and Biotechnology. 79:69-75. 2008
- Expression profiles of iron-related genes in the intestine and liver of young pigs fed three types of dietary inulin. Journal of Animal Science. 86:696. 2008
- Fe and Zn bioavailability from red (merlot) and white (great northern) bean-based (Phaseolus vulgaris) diets fed to anemic young pigs. FASEB Journal. 22. 2008
- Impact of Se-glutathione peroxidase-1 (GPX1) null on liver and plasma lipid profiles of male mice fed two dietary levels of fat. FASEB Journal. 22. 2008
- Impacts of dietary supplemental phytase and inulin on bone mechanical and chemical properties of young pigs. FASEB Journal. 22. 2008
- Iron bioavailability to piglets from red and white common beans (phaseolus vulgaris). Journal of Agricultural and Food Chemistry. 56:5008-5014. 2008
- Knockout of antioxidant enzyme Cu,Zn-superoxide dismutase impairs femoral mechanical performance of growing mice. Molecular Nutrition & Food Research. 52:1334-1339. 2008
- Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice. Diabetologia. 51:1515-24. 2008
- Null of Se-glutathione peroxidase-1 (GPX1) or Cu,Zn-superoxide dismutase (SOD1) suppresses murine pancreatic insulin synthesis and secretion. FASEB Journal. 22. 2008
- Overexpression of glutathione peroxidase induces obesity. Progress in Biochemistry and Biophysics. 35:140. 2008
- Phytase: Not just for environmental protection-novel roles in system physiology. Journal of Animal Science. 86. 2008
- Role of Se-glutathione peroxidase-1(GPX1) in catalyzing nitrotyrosine formation in murine hepatic proteins. FASEB Journal. 22. 2008
- Role of copper,zinc superoxide dismutase in catalyzing nitrotyrosine formation in murine liver. Free Radical Biology and Medicine. 45:611-618. 2008
- The pig as an experimental model for elucidating the mechanisms governing dietary influence on mineral absorption. Experimental Biology & Medicine. 233:651-664. 2008
- Adopting selected hydrogen bonding and ionic interactions from Aspergillus fumigatus phytase structure improves thermostability of Aspergillus niger phya phytase. Applied Environmental Microbiology. 73:3069-3076. 2007
- Altering the substrate specificity site of Aspergillus niger PhyB shifts the pH optimum to pH 3.2. Applied Microbiology and Biotechnology. 76:117-22. 2007
- Cecum is the major degradation site of ingested inulin in young pigs. Journal of Nutrition. 137:2399-2404. 2007
- Dietary inulin upregulates the expression of iron transporters, increases villus surface area, and alters microflora in iron deficient and adequate rats. FASEB Journal. 21. 2007
- Dietary supplementation of phytase enhanced bone density in young pigs fed a high phosphorus diet. FASEB Journal. 21. 2007
- Distribution of supplemental Escherichia coli AppA2 phytase activity in digesta of various gastrointestinal segments of young pigs. Journal of Animal Science. 85:1444-52. 2007
- Elevated pancreatic insulin synthesis and secretion in Se-glutathione peroxidase-1 (GPX1) overexpressing mice was associated with altered expression of PDX-1 and UCP2. FASEB Journal. 21. 2007
- Enzymatic Comparisons of Aspergillus niger PhyA and Escherichia coli AppA2 Phytases. Journal of Animal Science. 85:648. 2007
- Hydrolysis site and mode of action of supplemental dietary inulin in gastrointestinal tract of weanling pigs. FASEB Journal. 21. 2007
- Impact of GPX1 null and GPX4 hemizygosity on plasma lipid profiles of mice fed a high fat diet. FASEB Journal. 21. 2007
- Knockout of SOD1 or GPX1 led to decreased bone remodeling in young adult female mice. FASEB Journal. 21. 2007
- Supplemental Escherichia coli phytase and strontium enhance bone strength of young pigs fed a phosphorus-adequate diet. Journal of Nutrition. 137:1795-1801. 2007
- Copper, zinc-superoxide dismutase catalyzes peroxynitritemediated protein nitration in mouse tissue homogenates. FASEB Journal. 20. 2006
- Dietary inulin upregulates the expression of iron and zinc enterocyte membrane transporters and alters the microflora ecology in the pig intestine. Journal of Experimental Biology. 439. 2006
- Double-null of Cu,Zn-superoxide dismutase (SOD1) and selenium-dependent glutathione peroxidase-1 (GPX1) enhances resistance of mouse primary hepatocytes to acetaminophen toxicity. Experimental Biology & Medicine. 231:545-552. 2006
- Effect of Bread Baking on the Bioavailability of Hydrogen-Reduced Iron Powder Added to Unenriched Refined Wheat. Journal of Agricultural and Food Chemistry. 54:8362-8368. 2006
- Effects of supplemental dietary phytase and strontium on bone strength of weanling pigs fed a high phosphorus diet. Journal of Animal Science. 84:340. 2006
- Effects of supplemental inulin on utilization of iron in corn-soy diet by young pigs on hemoglobin synthesis. Journal of Animal Science. 84 (Suppl. 1):116. 2006
- Hyperinsulinemia in GPX1 overexpressing mice is independent of obesity. FASEB Journal. 20. 2006
- Impact of Cu,Zn-superoxide dismutase and Se-dependent glutathione peroxidase-1 Knockouts on acetaminophen-induced cell death and related signaling in murine liver. Experimental Biology & Medicine. 231:1726-1732. 2006
- Impacts of GPX4 haploid insufficiency on murine bone biomechanical properties. FASEB Journal. 20. 2006
- Lipopolysaccharide-induced oxidative stress is not potentiated by knockout of GPX1 and SOD1 in mice. FASEB Journal. 20. 2006
- Mice deficient in Cu,Zn-superoxide dismutase are resistant to acetaminophen toxicity. Biochemical Journal. 399:455-61. 2006
- Shifting the pH profile of Aspergillus niger PhyA phytase to match the stomach pH enhances its effectiveness as an animal feed additive. Applied Environmental Microbiology. 72:4397-4403. 2006
- Supplemental dietary inulin affects the bioavailability of iron in corn and soybean meal to young pigs. Journal of Nutrition. 136:3033-3038. 2006
- Supplemental dietary phytase and strontium improves bone traits of weanling pigs fed a phosphorus-adequate diet. Journal of Animal Science. 84(Suppl. 1):340-341. 2006
- An improved method for a rapid determination of phytase activity in animal feed. Journal of Animal Science. 83:1062-1067. 2005
- Double-knockout of GPX1 and SOD1 enhanced resistance of mouse primary hepatocytes to reactive nitrogen species-induced cell death. FASEB Journal. 19. 2005
- Effects of gpx4 haploid insufficiency on GPx4 activity, selenium concentration, and paraquat-induced protein oxidation in murine tissues. Experimental Biology & Medicine. 230:709-714. 2005
- Effects of supplemental inulin on utilization of iron in corn-soy diet by young pigs for hemoglobin synthesis. Journal of Animal Science. 83 (Suppl. 1):31. 2005
- Expression and characterization of a thermostable serine protease (TfpA) from Thermomonospora fusca YX in Pichia pastoris. Applied Microbiology and Biotechnology. 68:355-359. 2005
- Expression of Escherichia coli AppA2 phytase in four yeast systems. Biotechnol. Lett.. 27:327-334. 2005
- Fate of supplemental dietary phytase in the gastrointestinal tract of young pigs. Journal of Animal Science. 83(suppl. 1):388-389. 2005
- Impact of antioxidant enzyme knockout on murine bone integrity. Trans Orthop Res Soc. 30:651. 2005
- Impact of caloric restriction on insulin sensitivity in cellular glutathione peroxidase overexpressing mice. FASEB Journal. 19. 2005
- Impacts of chronic oxidative stress on the development of insulin resistance in mice overexpressing glutathione peroxidase-1 (GPX1). FASEB Journal. 19. 2005
- Knockout of Cu, Zn-superoxide dismutase (SOD1) alters acetaminophen (APAP) metabolism in mice. FASEB Journal. 19. 2005
- Knockout of Cu, Zn-superoxide dismutase (SOD1) alters acetaminophen (APAP) metabolism in mice. FASEB Journal. 19. 2005
- New developments in selenium toxicity. Journal of Animal Science. 83(suppl. 1):333. 2005
- New roles of an old selenoenzyme: evidences from glutathione peroxidase-1 null and overexpressing mice. Journal of Nutrition. 135:2295-2298. 2005
- Supplemental dietary phytase improves growth and bone development of young pigs fed a phosphorus-adequate diet. FASEB Journal. 19. 2005
- Supplemental inulin improves utilization of iron in plant-based diet by young pigs for hemoglobin synthesis. FASEB Journal. 19. 2005
- An improved method for the rapid determination of phytase activity in animal feeds. Journal of Animal Science. 82(suppl. 1):330. 2004
- Comparative effects of supplemental phytase on phytate-phosphorus release and bone development at two levels of dietary phosphorus. FASEB Journal. 18. 2004
- Crystallographic Snapshots of Aspergillus fumigatus Phytase, Revealing Its Enzymatic Dynamics . Structure. 12:1575-1583. 2004
- Effect of chronic oxidative stress and glutathione peroxidase-1 (gpx1) knockout on insulin function in mice. FASEB Journal. 18. 2004
- Expression of improved phytases in yeast and biochemical characterization. Methods in Biotechnology. 17:209-224. 2004
- Insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase-1. FASEB Journal. 18. 2004
- Knockout of cu,zn-superoxide dismutase (SOD1) abolishes acetaminophen (apap)-induced toxicity in mice. FASEB Journal. 18. 2004
- Shifting the pH profile of Aspergillus niger PhyA phytase improves its efficacy in pig diets. Journal of Animal Science. 82(suppl. 1):253. 2004
- Singular and combined effects of three fungal phytases with a bacterial phytase in corn-soy diets for young pigs. Journal of Animal Science. 82:1725-1731. 2004
- The acetaminophen-mediated hepatic cell death and signaling is affected by knockout of two antioxidant enzymes. FASEB Journal. 18. 2004
- Comparison of extracellular Escherichia coli AppA phytases expressed in Streptomyces lividans and Pichia pastoris. Biotechnology Letters. 25:827-831. 2003
- Effect of supplemental myo-inositol in diets for weanling pigs. Journal of Animal Science. 81 (suppl. 1):256. 2003
- Effectiveness of an experimental consensus phytase in improving dietary phytate-phosphorus utilization by weanling pigs. Journal of Animal Science. 81:2751-2757. 2003
- Efficacy of E. coli phytase expressed in yeast on phosphorus utilization and bone mineralization in turkey poults. Poultry Science. 82:1726-1732. 2003
- Efficacy of E. coli phytases expressed in yeast for releasing phytate-bound phosphorus in young chicks and pigs. Journal of Animal Science. 81:474-483. 2003
- Impacts of glutathione peroxidase-1 knockout on the protection by injected selenium against the pro-oxidant-induced liver aponecrosis and signaling in selenium-deficient mice. Free Radic. Biol. Med.. 34:918-927. 2003
- Low levels of glutathione peroxidase-1 activity in selenium-deficient mouse liver affect c-Jun N-terminal kinase activation and p53 phosphorylation on Ser-15 in the pro-oxidant-induced aponecrosis. Biochem J.. 370:927-934. 2003
- Phytase biotechnology: a fast developing field. Biotech. Lett.. 25:1787-1794. 2003
- Functional expression of kerA gene from Bacillus licheniformis in Pichia pastoris. Biotechnol. Lett.. 24:631-636. 2002
- Site-directed mutagenesis of Aspergillus niger NRRL 3135 phytase at residue 300 to enhance catalysis at pH 4.0. Biochem. Biophys. Res. Comm.. 297:1016-1020. 2002
- Biotechnological development of effective phytases for mineral nutrition and environmental protection. Appl. Microbiol. Biotechnol.. 57:474-481. 2001
- Comparative impacts of glutathione peroxidase-1 gene knockout on reactive oxygen and nitrogen species-induced oxidative stress in mouse hepatocytes. Biochem. J.. 359:687-695. 2001
- Glutathione peroxidase-1 gene knockout on body antioxidant defense in mice. BioFactors. 14:93-99. 2001
- Lipopolysaccharide and interferon-(-induced nitric oxide production and protein oxidation in mouse peritoneal macrophages are affected by glutathione peroxidase-1 gene knockout. Free Radic. Biol. Med.. 31:450-459. 2001
- Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxyntrite-induced apoptosis and signaling. Journal of Biological Chemistry. 276:43004-43009. 2001
- Phytase and citric acid supplementation in whole-wheat bread improves phytate-phosphorus release and iron dialyzabilitiy. Journal of Food Science. 66:614-619. 2001
- A new phytase expressed in yeast effectively improves the bioavailability of phytate phosphorus to weanling pigs. Journal of Animal Science. 78:668-674. 2000
- Biochemical characteristics of cloned Aspergillus fumigatus phytase (phyA). Biochem. Biophys. Res. Commun. 275:279-285. 2000
- Expression of Aspergillus fumigatus phytase gene in Pichia pastoris and characterization of the recombinant enzyme. Biochem. Biophys. Res. Comm.. 268:373-378. 2000
- Meat enhances nonheme iron absorption in pigs. Nutrition Research. 20:1749-1759. 2000
- Nutritional benefits of phytase and dietary determinants of its efficacy. Journal of Applied Animal Research. 17:97-112. 2000
- Phytase activity in Aspergillus fumigatus isolates. Biochem. Biophys. Res. Comm.. 275:759-763. 2000
- Preferential resistance of dopaminergic neurons to the toxicity of glutathione depletion is independent of cellular glutathione peroxidase and is mediated by tetrahydrobiopterin. J. Neurochem.. 74:2305-2314. 2000
- Site-directed mutagenesis improves catalytic efficiency and thermostability of Escherichia coli pH 2.5 acid phosphatase/phytase expressed in Pichia pastoris. Arch. Biochem. Biophys.. 382:105-112. 2000
- Cloning, sequencing, and expression of an Escherichia coli phosphatase/phytase gene (appA2) isolated from pig colon. Biochem. Biophys. Res. Comm.. 257:117-123. 1999
- Different sensitivity of recombinant Aspergillus niger phytase (r-PhyA) and Escherichia coli pH 2.5 acid phosphatase (r-AppA) to trypsin and pepsin in vitro. Arch. Biochem. Biophys.. 365:262-267. 1999
- Expression of an Aspergillus niger phytase gene (phyA) in Saccharomyces cerevisiae. Applied and Environmental Microbiology. 65:1915-1918. 1999
- High levels of dietary vitamin E do not replace cellular glutathione peroxidase in protecting mice from oxidative stress. Journal of Nutrition, The. 129:1951-1957. 1999
- Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress. Free Radic. Biol. Med.. 27:605-611. 1999
- Phytase improves iron bioavailability for hemoglobin synthesis in young pigs. Journal of Animal Science. 77:2135-2142. 1999
- Role of glycosylation in the functional expression of an Aspergillus niger phytase (phyA) in Pichia pastoris. Arch. Biochem. Biophys.. 364:83-90. 1999
- Selenium-dependent cellular glutathione peroxidase protects mice against a pro-oxidant induced oxidation of NADPH, NADH, lipid, and protein. FASEB Journal. 13:1467-1475. 1999
- Addition of wheat middlings, microbial phytase, and citric acid to corn-soybean meal diets for growing pigs may replace inorganic phosphorus supplementation. Journal of Animal Science. 76:2649-2656. 1998
- Cellular glutathione peroxidase is the mediator of body selenium to protect against paraquat lethality in transgenic mice. Journal of Nutrition. 128:1070-1076. 1998
- Dietary selenium supplementation is required to support full expression of three seleniumdependent glutathione peroxidases in various tissues of weanling pigs. Journal of Nutrition. 128:130-135. 1998
- Knockout of cellular glutathione peroxidase affects selenium-dependent parameters similarly in mice fed adequate and excessive dietary selenium. BioFactors. 7:311-321. 1998
- Cellular glutathione peroxidase knockout mice express normal levels of selenium-dependent plasma and phospholipid hydroperoxide glutathione peroxidases in various tissues. Journal of Nutrition. 127:1445-1450. 1997
- Comparison of age-related differences in expression of phospholipid hydroperoxide glutathione peroxidase mRNA and activity in various tissues of pigs.. Comp. Biochem. Physiol.. 117B:109-114. 1997
- Effects of dietary selenium and vitamin E concentration on phospholipid hydroperoxide glutathione peroxidase expression in reproductive tissues of pubertal maturing male rats. Biol. Trace Element Res.. 59:195-206. 1997
- Overexpression of cellular glutathione peroxidase did not affect expression of plasma glutathione peroxidase or phospholipid hydroperoxide glutathione peroxidase in mice offered diets adequate or deficient in selenium. Journal of Nutrition. 127:675-680. 1997
- Supplemental phytases of microbial and cereal sources improves dietary phytate phosphorus utilization by pigs from weaning through finishing. Journal of Animal Science. 75:1017-1025. 1997
- Glutathione peroxidase and phospholipid glutathione peroxidase are differentially regulated in rats by dietary selenium. Journal of Nutrition. 125:1438-1446. 1995
- Calcium level affects the efficacy of supplemental microbial phytase in corn-soybean meal diets of weanling pigs. Journal of Animal Science. 72:139-143. 1994
- Supplemental microbial phytase improves bioavailability of dietary zinc to weanling pigs. Journal of Nutrition. 123:1117-1123. 1993
- Supplementing corn-soybean meal diets with microbial phytase improves phytate phosphorus utilization by weanling pigs. Journal of Animal Science. 71:3359-3367. 1993
- Supplementing corn-soybean meal diets with microbial phytase maximizes phytate phosphorus utilization by weanling pigs. Journal of Animal Science. 71:3368-3375. 1993
- Effects of molybdenum supplementation on the metabolism of molybdenum in selenium-deficient growing pigs. J. Sichuan Agr. Univ.. 9:534-538. 1991
- The effect of different dietary supplemental molybdenum levels on hepatic and renal sulfite oxidase activity and urine sulfate and sulfite excretion in selenium-deficient growing pigs. J. Sichuan. Agr. Univ.. 9:644-650. 1991
- The changes of platelet glutathione peroxidase activity in pigs fed different dietary selenium supplemental levels. J. Sichuan Agr. Univ.. 4:56-61. 1985
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article
- Cereal phytase may improve phosphorous bioavailability. Feedstuffs. 69:12-15. 1997
- Phytase: A viable solution to phosphorus nutrition in poultry production 1995
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book
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booksection
- Bioavailability: Mineral Elements. In:Encyclopedia of Animal Science, 2004
- Mineral Elements: Micro (trace). In: Encyclopedia of Animal Science 2004
- Phytases. In:Encyclopedia of Animal Science, 2004
- Analysis of phospholipid hydroperoxide glutathione peroxidase mRNA 2002
- In vivo antioxidant role of GPX1: Evidence from the knockout mice. Vol. 347. 2002
- Differential regulation and function of glutathione peroxidases and other selenoproteins 2001
- Trace Elements in Animal Nutrition. Vol. 4. 1991
- The energy and protein needs of pigs at finishing stage 1982
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chapter
- Invited Review: Algae as a source of animal feeds. Advances in Animal Nutrition. 270-284. 2012
- Phytases:types, structure, and applications, in Industrial Enzymes: Structure, Function and Applications. Springer. 505-529. 2007
- New roles of glutathione peroxidase-1in oxidative stress and diabetes. In: Selenium, its molecular biology and role in human health. Springer US. 2006
- Inositol phosphate in animal nutrition: dietary manipulation and phosphorus excretion by animals. In: Inositol Phosphates in the Soil-Plant-Animal System. CABI Publishing. 133-149. 2005
- Of pigs and people. Swine Nutrition. 3-18. 2000
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conference paper
- New insights on defatted algal biomass as single cell protein for animal feed.. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers. 94-96. 2012
- Developing biotechnology to convert poultry feathers into high-quality protein. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers, the 72 meeting, October 19-21, 2010, East Syracuse, NY.. 94. 2010
- GPX1 on type 2 diabetes-like syndrome. The 9th International Symposium on Selenium in Biology and Medicine (Selenium 2010). 2010
- Impacts of dietary Se deficiency on the development of type 2 diabetes-like phenotypes in the GPX1 overexpressing mice. The 9th International Symposium on Selenium in Biology and Medicine (Selenium 2010), May 31-June 4, 2010. 2010
- Pigs as a model to study regulations of selenogenome by dietary Se and fat. The 9th International Symposium on Selenium in Biology and Medicine (Selenium 2010), May 31-June 4, 2010. 2010
- Demoliton and construction on the road to a better understanding of phytase. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers. 2008
- Hidden roles of Se-GPX1 and Cu.Zn-SOD1. Proceedings of the 13th International Meeting on Trace Element in Man and Animals. 45-46. 2008
- Nicotianamine, a novel iron enhancer in rice grain. Proceedings of the XIV International Symposium on Iron Nutrition and Interactions in Plants, and Annual Meeting of HarvestPlus-China 2008. 140. 2008
- Probiotics and iron bioavailability: using the piglet as a model to study effects and mechanisms. Proceedings of the 13th International Meeting on Trace Element in Man and Animals. 50. 2008
- Double knockout of Cu,Zn-superoxide dismutase (SOD1) and selenium-dependent glutathione peroxidase-1 (GPX1) protects mice against acetaminophen toxicity. Book of Abstracts. 2005
- Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase. Proc. Natl. Acad. Sci.. 8852-8857. 2004
- Impact of selenium-dependent cellular glutathione peroxidase on glucose metabolism and antioxidant defense. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers. 209-217. 2003
- Innovative tools to assess body antioxidant status and selenium/vitamin E nutrition. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers. 101-105. 2001
- Antioxidant impacts of glutathione peroxidase 1 gene knockout in mice. 7th International Symposium on Selenium in Biology and Medicine at Selenium 2000. 2000
- Expressing and designing phytase for nutrition and environmental protection. Proc. Agr. of the New Century: Managing Bio-Resources and Bio-Diversity. 47-52. 2000
- New methods for using and delivering phytase to animals. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers. 57-64. 2000
- Cellular glutathione peroxidase protects mice against lethal oxidative stress induced by various doses of diquat. Proc. Soc. Exp. Biol. Med.. 164-169. 1999
- Using transgenic mice to study selenium nutrition. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers. 58-64. 1999
- Development of a new phytase and its effect on dietary phosphorus and iron bioavailabilities to pigs. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers. 166-168. 1998
- Dietary use of cereal and microbial phytases and the metabolic effects of growing pigs. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers. 149-154. 1997
- Overexpression of the phytase gene in microbial systems and the application in animal and human nutrition. 12th Annual Cornell Biotechnology Symposium. 1996
- Responses of cellular glutathione peroxidase overexpressing mice to two levels of dietary selenium concentrations. The Sixth International Symposium on Selenium in Biology and Medicine. 18. 1996
- What level of selenium should we supplement to diets for young pigs?. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers. 83-86. 1996
- Development of phytase overexpressing bacterial strains to reduce phosphorus pollution from animal waste. 11th Annual Cornell Biotechnology Symposium. 1995
- Supplemental microbial phytase in corn-soybean meal diets releases sufficient phosphorus for pigs from weaning to finishing. Proceedings of the Cornell Nutrition Conference for Feed Manufacturers. 149-152. 1995
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document part
- Association of selenoprotein gene expression with pancreatic atrophy in chicks. 2012
- Defatted algae biomass may replace one-third of soybean meal in diets for laying hens. 2012
- Dietary Se on type 2 diabetes-like phenotypes of GPX1 overexpressing mice.. 151-742. 2012
- Effects of defatted algal meal on growth performance and plasma biochemical profiles of weanling pigs 2012
- Impacts of RegIIIß inactivation on murine hepatic protein nitration induced by acetaminophen. 2012
- Is selenium antioxidative or diabetogenic? 2012
- Molecular mechanism for inulin effect on iron bioavailability. 2012
- Selenium and diabetes: evidence from animal studies. 2012
- A functional genomics view of selenium in energy metabolism, obesity, and diabetes 2010
- Cloning of a porcine trypsinogen gene and over-production of the protein as a feed additive 2010
- Cloning of porcine pancreatic α-amylase gene and characterization of the enzyme over-expressed in Pichia pastoris 2010
- Cloning of the porcine selenoprotein V gene and its RNA abundance in different tissues of young pigs fed three levels of dietary selenium concentrations 2010
- Developing an efficient E. coli expression system for producing a recombinant antimicrobial peptide plectasin 2010
- Effects of dietary Se deficiency on the metabolic phenotype and glucose metabolism-related gene expression of the diet-restricted GPX1 overexpressing mice 2010
- Effects of dietary Se deficiency or excess on gene expression of 13 novel selenoproteins in growing pigs 2010
- Gene expression profile of selenoproteins in an obese pig model induced by a high-fat diet 2010
- Heterologous expression of a truncated bovine lactoferrin gene in E. coli to produce a novel antimicrobial peptide 2010
- Over-supplementing dietary selenium induced insulin resistance in gestating rats 2010
- Selenocysteine abundance was decreased in the hepatic GPX1 protein of SOD1-/- mice 2010
- Serum from pigs fed a high-Se diet inhibits growth of human lung cancer cells 2010
- Antioxidant enzymes and diabetes: foes or friends? . 56. 2009
- Cloning and expression of porcine carboxypeptidase A1 for feed application 2009
- Comparative effects of Escherichia coli AppA2 and Aspergillus niger PhyA phytases on bone property of weanling pigs fed a high phosphorus diet 2009
- Comparative regulation of novel porcine selenoprotein gene expression in endocrine tissues and liver by dietary selenium 2009
- Effects of dietary Se deficiency or excess on gene expression of 13 novel selenoproteins in growing pigs 2009
- Expression and purification of porcine pancreatic carboxypeptidase B in a yeast system 2009
- Genetic engineering of an Escherichia coli mutant phytase for thermostability does not affect the enzymatic efficacy in a diet for young pigs 2009
- Heterologous expression of recombinant porcine elastase 2 as a feed enzyme 2009
- Knockout of SOD1 decreased GPX1 activity but not GPX1 protein in murine liver 2009
- Old obese GPX1 overexpressing mice do not develop overt type 2 diabetes 2009
- Relative distribution of protein and non-protein bound Se in liver and muscle of growing pigs fed two sources of dietary Se 2009
- Three types of dietary inulin exerted similar impacts on expression profiles of iron-related genes in the intestine and liver of young pigs 2009
- Comparative effectiveness of Aspergillus niger wild-type and variant phytases in the hydrolysis of phytate-phosphorous in the diets for weanling pigs. 99. 2003
- Effect of reduced GPX4 activity on paraquat-induced protein oxidation in the lung of GPX4 hemizygous mice 2003
- Effect of supplemental myo-inositol in diets for weanling pigs. 256. 2003
- Glutathione peroxidase-1 (GPX1) knockout on body responses to chronic and moderate oxidative stress in old mice 2003
- Impact of cellular glutathione peroxidase-1 (GPX1) knockout and overexpression on acetaminophen (APAP)-induced antioxidant system changes in mice 2003
- Overexpression of cellular glutathione peroxidase-1 (GPX1) results in elevated plasma glucose and thyroxine (T4) concentrations 2003
- Efficacy of Phytex phytase on phosphorus utilization and bone mineralization in turkey poults. 13. 2002
- Efficacy of different phytase products for young chicks and pigs. 75. 2002
- Expression, engineering, and testing of phytases. 54. 2002
- How do these tools help study nutrient function?. 81. 2002
- Impacts of site directed mutations and expression systems on efficacy of Escherichia coli phytases in diets for weanling pigs. 37-38. 2002
- Microarray analysis of bone metabolism gene expression in glutathione peroxidase-1 (GPX1) knockout mice 2002
- Overexpression of cellular glutathione peroxidase (GPX1) sensitizes murine hepatocytes to peroxynitrite-induced cytotoxicity 2002
- Phosphorus efficacy of E. coli phytase in young chicks. 11. 2002
- Relative effectiveness of consensus phytase to inorganic phosphorus and an Escherichia coli phytase in diets for weanling pigs. 38. 2002
- Differential protection of cellular glutathione peroxidase (GPX1) and other selenoproteins against pro-oxidant-induced cytotoxicity in mouse hepatocytes 2001
- Evaluation of Streptomyces lividans and Pichia pastoris as extra-cellular expression systems for Escherichia coli phytase. 320. 2001
- Glutathione peroxidase-1 (GPX1) knockout produces opposite impacts on diquat- and peroxynitrite-induced apoptosis and related signaling in murine hepatocytes 2001
- Minute glutathione peroxidase-1 (GPX1) activity is able to protect murine liver against pro-oxidant-induced apoptosis 2001
- Singular and combined efficacy of two new microbial phytases in corn-soy or corn-soy-wheat diets for young pigs. 107. 2001
- Cellular glutathione peroxidase (GPX1) and other selenium-dependent factors protect murine red blood cell membrane integrity 2000
- Efficacy and pH dependence of phytate-phosphorus hydrolysis by four different phytases are modulated by buffer and substrate specificities. 189. 2000
- Impacts of cellular glutathione peroxidase (GPX1) knockout on mouse susceptibility to moderate oxidative stress 2000
- Knockout of cellular glutathione peroxidase (GPX1) has different impacts on protein carbonyl and nitrotyrosine formation in primary hepatocytes 2000
- Reducing phytate in whole wheat bread by phytase and citric acid improves phosphorus and iron release 2000
- Supplementing Natuphos with an Escherichia coli phytase expressed in yeast improve its in vitro and in vivo efficacy. 130. 2000
- A new phytase expressed in yeast improves phytate phosphorus bioavailability to weanling pigs. 175. 1999
- Effects of feeding cane molasses at two levels of crude protein in finishing diets on growth performance, carcass traits and pork quality. 192. 1999
- In vivo and in vitro evidence for antioxidant role of selenium-dependent cellular glutathione peroxidase in protecting against diquat toxicity 1999
- Pigs fed phytase-supplemented diets are more prone to the adverse effects of an elevated Ca:P ratio than those fed inorganic P-supplemented diets. 277. 1999
- Addition of citric acid enhances the efficacy of supplemental microbial and cereal phytases in corn-soy diets for growing pigs. 177. 1998
- Effect of diets containing cane molasses on nitrogen metabolism of finishing pigs. 187. 1998
- Effect of lysine supplementation on N metabolism of finishing barrows fed diets containing cane molasses. 169. 1998
- Protection of cellular glutathione peroxidase against paraquat lethality in mice is irreplaceable by high levels of dietary vitamin E 1998
- Selenium-dependent cellular glutathione peroxidase protects against paraquat-induced oxidation in mice 1998
- Supplemental dietary phytase improves iron bioavailability to weanling pigs. 178. 1998
- Transgenic models: role in understanding pathophysiology of related antioxidant enzymes. 16. 1998
- Dietary iron bioavailability does not affect liver iron stores in iron-normal or iron-loaded swine 1997
- Effects of cereal and microbial phytases on dietary lysine utilization by growing pigs. 185. 1997
- Effects of cereal and microbial phytases on phytate-phosphorus utilization, intestinal phytase and alkaline phosphatase activities, and plasma glutathione peroxidase in growing pigs. 183. 1997
- Knockout of cellular glutathione peroxidase did not affect the expression of the other two selenoperoxidases in mice 1997
- Dietary selenium at 0.1 mg/kg is inadequate for young pigs to maximize tissue expression of selenoperoxidases 1996
- Effects of dietary selenium deficiency on activity expression of selenoperoxidase in gastrointestinal tissues of pigs 1996
- Response of selenoperoxidase activity expression in pig tissues to porcine somatotropin administration. 195. 1996
- Response of selenoperoxidase activity expression in pig tissues to porcine somatotropin administration 1996
- Effect of dietary selenium on phospholipid hydroperoxide glutathione activity and gene expression in rats 1995
- Expression of selenium-dependent phospholipid hydroperoxide glutathione peroxidase activity in tissues of young pigs is influenced by development 1995
- Overexpression of phospholipid hydroperoxide glutathione peroxidase in FL5.12 cells partially protects against AZO-initiated peroxidation 1995
- Effects of dietary phytase, calcium, and vitamin D on plasma mineral concentration in weanling pigs. 176. 1993
- Selenium toxicity in stable selenoperoxidase-transfected MOD cells 1993
- Improvement of phytate phosphorus utilization by a microbial phytase in weanling pigs. 374. 1991
- Effects of dietary fiber and antibiotics on biotin nutrition in young pigs. 101. 1990
-
report
- Determination of dietary phytase activity in maximizing utilization of phytate phosphorus in a corn-soybean meal diet for weanling pigs and its equivalence to inorganic phosphorus supplementation 1992
- Influence of dietary phytase activity on utilization of phytate phosphorus in a corn- soybean meal diet for weanling pigs 1992
- Effect of dietary fiber and antibiotics on biotin nutrition in young pigs. 71-77. 1990
- Extinction of supplemental glutathione given orally, intravenously or intramuscularly to fed and fasting young pigs. 60-70. 1990
- Advances in selenium research 2008
- Impacts of inulin on gut microbiota and mineral absorption 2008
- Biotechnological Approaches to Manure Nutrient Management, Council for Agricultural Science and Technology 2006
featured in archived article
Teaching
teaching overview
- Animal science and human health (role of animal food in human nutrition and health, use of animals in biomedical research, bird flu, mad cow disease, antibiotic resistance, and issues related to use of growth hormones in animal production) Animals in Biomedical Research (various models for human diseases) Advanced Mineral Nutrition (metabolism, gene expression, relation to chronic disease, and biofortification)
teaching activities
- ANSC-7900: Graduate-Level Thesis Research - Spring 2013
- ANSC-8900: Master's Level Thesis Research - Spring 2013
- ANSC-9900: Doctoral-Level Thesis Research - Spring 2013
- FDSC-5000: Master of Professional Studies (Agriculture) Project - Spring 2013
- FDSC-6960: Graduate Internship in Food Science - Spring 2013
- FDSC-8900: Master's Level Thesis Research - Spring 2013
- FDSC-9900: Doctoral-Level Thesis Research - Spring 2013
- ANSC-3980: Animals in Biomedical Research - Fall 2012
- ANSC-7900: Graduate-Level Thesis Research - Fall 2012
- ANSC-8900: Master's Level Thesis Research - Fall 2012
- ANSC-9900: Doctoral-Level Thesis Research - Fall 2012
- FDSC-5000: Master of Professional Studies (Agriculture) Project - Fall 2012
- FDSC-6960: Graduate Internship in Food Science - Fall 2012
- FDSC-8900: Master's Level Thesis Research - Fall 2012
- FDSC-9900: Doctoral-Level Thesis Research - Fall 2012
- ANSC-7900: Graduate-Level Thesis Research - Spring 2012
- ANSC-8900: Master's Level Thesis Research - Spring 2012
- ANSC-9900: Doctoral-Level Thesis Research - Spring 2012
- FDSC-5000: Master of Professional Studies (Agriculture) Project - Spring 2012
- FDSC-6960: Graduate Internship in Food Science - Spring 2012
- FDSC-8900: Master's Level Thesis Research - Spring 2012
- FDSC-9900: Doctoral-Level Thesis Research - Spring 2012
- ANSC-7900: Graduate-Level Thesis Research - Fall 2011
- ANSC-8900: Master's-Level Thesis Research - Fall 2011
- ANSC-9900: Doctoral-Level Thesis Research - Fall 2011
- FDSC-5000: Master of Professional Studies (Agriculture) Project - Fall 2011
- FDSC-6960: Graduate Internship in Food Science - Fall 2011
- FDSC-8900: Masters-Level Thesis Research - Fall 2011
- FDSC-9900: Doctoral-Level Thesis Research - Fall 2011
Service
outreach overview
- Help inform and educate the public of biological science and research Give lectures to high school students and provide research opportunity to them
service to the profession
- ASAS-Wilson Pond Appreciation Club Award committee Committee Member 2009 -
- Free Radical Biology and Medicine Society Member 2009 -
- Special Task Committee, ASN Committee Member 2008 -
- Standing committee of the Chinese National Association of Young Scientists and Technologists Committee Member 2006 -
- Chinese Association of Young Scientists and Technologists Committee Member 2006 -
- International Parent Committee on Trace Elements in Man and Animal Committee Member 2005 -
- America Society for Microbiology Member 2005 -
- British Biochemical Society Member 2005 -
- Chinese-American Diabetes Association Member 2005 -
- Ministry of Education Reviewer of applications for Cheung Kong Scholar, Endowed Professor 2005 -
- NCCC-42 Swine Nutrition Committee Committee Member 2005 -
- The Oversea Chinese Biologist Association Member 2004 -
- Society for Experimental Biology and Medicine Member 2003 -
- Trace Element in Man and Animals Committee Member 2002 -
- Cornell Institute of Food Science Member 1998 -
- American Society for Nutrition
- Experimental Biology and Medicine
- Free Radical Biology and Medicine Society
- Phi Beta Delta Honor Society
- Sigma Xi
- Chinese Nutrition Research and Development, Center for Public Nutrition and Development, National Development and Reform Commission of China, Beijing Special Advisor for the 11th Five year plan 2005 - 2011
- Trace Elements in Man and Animals, International Conference Host - 2011
- AI-SPER-0203DF692AB000107F4 Chairperson 2005 - 2011
- Organization Committee of the 13th International Conference on Trace Elements in Man and Animals Committee Member 2007 - 2008
- AI-SPER-0203DF692AB0001097C Program Organizer 2007 - 2008
- AFIA Non-ruminant Nutrition Award Committee, American Society of Animal Science Committee Member 2006 - 2008
- HarvestPlus-China Annual Meeting and Advisory Meeting Organizer 2007
- Experimental Animal Nutrition RIS, ASN Chairperson 2006 - 2007
- Council for Agricultural Science and Technology, Task Committee Chairperson 2004 - 2006
- Task Force on Biotechnology and Animal Manure Nutrient Management, Council for Agricultural Science and Technology Chairperson 2004 - 2006
- American Society of Animal Science Member of Minority and Women Committee 2003 - 2006
- Steering Committee of Nutrient-Gene Interaction RIS Member 2003 - 2006
- American Society of Nutritional Sciences Chairperson 2003 - 2005
- Committee on Minerals and Toxic Substances in Diets and Water for Animals National Research Council, National Academy of Science Member 2003 - 2005
- AI-SPER-0203DF692AB00010809 Program Organizer 2005
- Office of Overseas Chinese affairs, the State Council of China to attend the 5th national meeting of high – technology symposium Delegation Member 2005
- HarvestPlus Advisory Committee Meeting Coordinator 2005
- Non-ruminant Nutrition Committee, American Society of Animal Science Committee Member 1999 - 2002
- Non-ruminant Nutrition Committee, American Society of Animal Science Chairperson - 2002
reviewer or editor for
- Broad Medical Research Program, Inflammatory Bowl Disease Grants
- Chinese Natural Science Foundation (Basic Biology Program)
- Division of Life Science, National Natural Science Foundation of China
- Harvest-Plus China Program, Seed research grant proposal
- Improving Human Nutrition for Optimal Health Program
- Improving Human Nutrition for Optimal Health Program
- Major Competitive Grants: Division of Life Science, National Natural Science Foundation of China
- NIFA/USDA
- NIH Study Section (INMP)
- NRICGP, USDA
- USDA National Research Initiative Competitive Grant Program (NRICGP)
Background
education and training
- University of Missouri 1995
- Ph.D. in Mineral Nutrition, Michigan State Univeristy 1993
- Sichuan Agricultural University 1985
- Hunan Agricultural University 1982
awards and honors
- President, 2014
- Special invitee of high intellectual expert delegation for the national celebration of the 60th anniversary of PRC, 2009
- Outstanding Overseas Young Scientist Collaboration Award, 2006
- Excellent Paper Award, 2006
- Endowed Professor, Chang Jiang Scholar, 2005
- Mead Johnson Award, National Award, 2005
- AFIA-Non-ruminant Nutrition Award, National Award, 2005
- Provost Award for Distinguished Scholarship, 2005
- Cornell Biotechnology Business Award, 2003
- Outstanding young scientist award, 1999
- Sigma Xi Graduate Student Award, 1992
- Graduate Student Special Recognition Award, 1992
- The 1000 People Plan Professor
- Special Delegation for 61th anniversary of PRC
- Honorary Citizen of Enshi, Hubei, China, September, 2011 by the government for contribution
- Special guest for the 62st Anniversary Celebration of the People’s Republic of China (Beijing, China; September 27-October 1, 2011)
Other
research keyword
- algal biomass
- biofuel production
- mineral, selenium, copper, iron, phytase, protease, biotechnology, environment, diabetes, obesity, biofortification, protein engineering, molecular nutrition