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Scott, Jeffrey Graham
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Positions
- Professor, Entomology (ENTOM), College of Agriculture and Life Sciences (CALS)
- Department Chairperson, Entomology (ENTOM), College of Agriculture and Life Sciences (CALS)
Research Areas
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Affiliations
member of graduate field
other Cornell affiliations
member of
- David R. Atkinson Center for a Sustainable Future (ACSF) Faculty Fellow
advisory group member
Extension
has primary specialization area
Research
research overview
- Our research is characterized by the four major areas below and seeks answers to both applied and basic questions. The techniques we use are varied and wide ranging. Insecticide resistance and evolutionary biology. Resistance is one of the major problems facing public health and agriculture. Resistance has been referred to as "instant evolution" and causes major disruption whenever vectors of human disease or pests of agriculture can no longer be controlled. We study resistance as both a problem for which we need practical solutions, as well as an intensely interesting problem in basic evolutionary biology. We specialize in investigating the mechanisms (biochemical and genetic), inheritance, management, fitness costs and population genetics of insecticide resistance. Insect genetics and molecular biology are active areas of research in our laboratory. We examine the genetic control and linkage of important traits (such as insecticide resistance), and we are now investigating the functions of a new gene repressor in insects which was recently identified by our group. We have also identified the recent "invasion" of a unique type of sex determination system in house fly populations in New York (male factor has moved to an autosome). The reason for the increasing frequency of this type of sex determination is one of many unanswered questions. Sex determination in house flies is studied to better understand the factors responsible for the differences in the linkage of the male determining factor in field populations. R. Hamm recently discovered that 100% of male house flies in Florida are autosomal males (M is on autosome 3) and 100% of the males in Maine are Y males. Her dissertation research is aimed at better understanding this phenomenon. Insecticide toxicology and metabolism studies are carried out to better understand the target sites of current and novel insecticides, as well as their pharmacodynamics (movement and fate within the organism). Studies have involved neuophysiological investigations into insecticide action as well as efforts to identify the enzymes involved in the metabolism of the insecticide.
research activities
principal investigator on
- CHARACTERIZATION OF THE TARGET SITE(S) OF IMIDACLOPRID awarded by BAYER CROPSCIENCE 2011 - 2012
- IDENTIFICATION OF THE MECHANISM OF ACTION OF A NOVEL ACARICIDE awarded by LANDIS INTERNATIONAL, INC 2010 - 2013
- STUDY OF RESISTANCE OF THE DIAMOND MOTH TO SPINOSAD awarded by DOW AGROSCIENCES LLC 2008 - 2013
- TAXONOMIC INDENTIFICATION 2011 awarded by US DEPT OF AGRICULTURE 2011
area(s) of concentration/expertise
keywords
- cytochrome P450
- evolution of insecticide resistance
- house fly
- insecticide toxicology
- mosquito
- nicotinic acetylcholine receptor
- sex determination
- voltage gated sodium channel
submitted impact statement
- Pesticides, the environment, and human health
- Insecticide resistant strains of house flies (Musca domestica) show limited cross-resistance to chlorfenapyr
- Insecticide metabolism in insects involves only a few of nearly 100 cytochrome P450 isoforms
- Indoxacarb resistance in Musca domestica or the house fly
- INSECTICIDE RESISTANCE IN CULEX PIPIENS FROM NEW YORK
- Evolutionary Plasticity of Insecticide Resistance
- Evaluation of novel insecticides for control of mosquitoes
Publications
individual publications
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academic article
- Antisense sequencing improves the accuracy and precision of A-to-I editing measurements using the peak height ratio method.. BMC Research Notes. 5:63. 2012
- Diversity and frequencies of genetic mutations involved in insecticide resistance in field populations of the house fly (Musca domestica L.) from China.. Pesticide Biochemistry and Physiology. 102:153-159. 2012
- Multiple cytochrome P450s overexpressed in pyrethroid resistant house flies (Musca domestica) . Pesticide Biochemistry and Physiology. 104:252-260. 2012
- Multiple evolutionary origins of knockdown resistance (kdr) in pyrethroid-resistant Colorado potato beetle, Leptinotarsa decemlineata.. Pesticide Biochemistry and Physiology. 104:192-200. 2012
- Multiple origins of kdr-type resistance in the house fly, Musca domestica.. PLoS One. 7. 2012
- Reduction of dADAR affects the sensitivity of spinosad and imidacloprid to Drosophila melanogaster Pestic.. Pesticide Biochemistry and Physiology. 104:163-169. 2012
- Hormone receptor-like in 96 and broad-complex modulate phenobarbital induced transcription of cytochrome P450 CYP6D1 in Drosophila S2 cells. Insect Molecular Biology. 20:87-95. 2011
- Investigations of the constitutive overexpression of CYP6D1 in the permethrin resistant LPR strain of house fly (Musca domestica). Pesticide Biochemistry and Physiology. 100:130-134. 2011
- A review of the interactions between multiple insecticide resistance loci. Pesticide Biochemistry and Physiology. 97:123-128. 2010
- Differences in development, glycogen and lipid content associated with cytochrome P450-mediated permethrin resistance in Culex pipiens quinquefasciatus (Diptera: Culicidae).. J. Med. Entomol.. 47:188-198. 2010
- Is Apis mellifera more sensitive to insecticides than other insects?. Pest Management Science. 66:1171-1180. 2010
- Response of a generalist herbivore Trichoplusia ni to jasmonate-mediated induced defense in tomato. Journal of Chemical Ecology. 36:490-499. 2010
- Transcripts of the nicotinic acetylcholine receptor subunit gene Pxylα6 with premature stop codons are associated with spinosad resistance in diamondback moth, Plutella xylostella. Invertebrate Neuroscience. 10:25-33. 2010
- Use of isogenic strains indicates CYP9M10 is linked to permethrin resistance in Culex pipiens quinquefasciatus. Insect Molecular Biology. 19:717-726. 2010
- A high frequency of male determining factors in male house flies, Musca domestica L. (Diptera: Muscidae), from Ipswich, Australia. Journal of Medical Entomology. 46:169-172. 2009
- A case for sequencing the genome of the house fly, Musca domestica (Diptera: Muscidae) . J. Mol. Entomol. 46:175-182. 2009
- Frequencies and evolution of organophosphate insensitive acetylcholinesterase alleles in laboratory and field populations of the house fly, Musca domestica L. . Pesticide Biochemistry and Physiology. 95:6-11. 2009
- Multiplicative interaction between the two major mechanisms of permethrin resistance, cytochrome P450-monooxygenase detoxification and kdr, in mosquitoes. Journal of Evolutionary Biology. 22:416-423. 2009
- Selective advantage for IIIM males over YM males in competition over 12 generations in Musca domestica L. (Diptera: Muscidae). Environmental Entomology. 38:499-504. 2009
- The effect of three environmental conditions on the fitness of cytochrome P450 monooxygenase-mediated permethrin resistance in Culex pipiens quinquefasciatus. BMC Evolutionary Biology. 9:42. 2009
- Transcriptional diversity and allelic variation in nicotinic acetylcholine receptor subunits of the red flour beetle, Tribolium castaneum. Information Processing and Management. 18:233-242. 2009
- Changes in the frequency of YM versus IIIM in the house fly, Musca domestica L., under field and laboratory conditions. Genetics Research. 90:493-498. 2008
- Comparison of two acetylcholinesterase gene cDNAs of the lesser mealworm, Alphitobius diaperinus, in insecticide susceptible and resistant strains. Arch. Insect Biochem. Physiol. 67:130-138. 2008
- The genome of the model beetle and pest Tribolium castaneum. Tribolium Genome Sequencing Consortium. 452:949-955. 2008
- Unraveling the mystery of spinosad resistance in insects. J. Pestic. Sci. 33:221-227. 2008
- Characterization of the nicotinic acetylcholine receptor subunits Mdα5 and Mdβ3 on autosome 1 of Musca domestica indicate they are not involved in spinosad resistance. Insect Biochemistry and Molecular Biology. 16:691-701. 2007
- Cytochrome P450 monooxygenase-mediated permethrin resistance confers limited and larval specific cross-resistance in the southern house mosquito, Culex pipiens quinquefasciatus. Pesticide Biochemistry and Physiology. 89:175-184. 2007
- Dynamics of insecticide resistance alleles in two different climates over an entire field season. Insect Biochem. Molec. Biol. 37:550-558. 2007
- Monitoring susceptibility of house flies (Musca domestica L.) in the United States to imidacloprid. J. Agric. Urban Entomol.. 23:195-200. 2007
- Susceptibility of field collected house flies to spinosad before and after a season of use. J. Agric. Urban Entomol.. 23:105-110. 2007
- The A302S mutation in Rdl that confers resistance to cyclodienes and limited cross-resistance to fipronil is undetectable in field populations of house flies from the USA. Pesticide Biochemistry and Physiology. 88:66-70. 2007
- The nicotinic acetylcholine receptor subunit gene Mdalpha2 from the housefly, Musca domestica. Arch. Insect Biochem. Molec. Biol. 64:30-42. 2007
- The nicotinic acetylcholine receptor subunit gene Mdα6 from Musca domestica is diversified via post transcriptional modification. Insect Biochemistry and Molecular Biology. 16:325-334. 2007
- Deletion of Cyp6d4 does not alter toxicity of insecticides to Drosophila melanogaster Pestic. Biochem. Physiol. 84:236-242. 2006
- Evaluation of novel insecticides for control of dengue vector Aedes aegypti (Diptera: Culicidae). Journal of Medical Entomology. 43:55-60. 2006
- Frequencies of the pyrethroid resistance alleles of Vssc1 and CYP6D1 in house flies from the eastern United States. Insect Biochemistry and Molecular Biology. 15:157-167. 2006
- Resistance to cyfluthrin and tetrachlorvinphos in the lesser mealworm, Alphitobius diaperinus, collected from the eastern United States. Pest Management Science. 62:673-677. 2006
- Role of the transcriptional repressor mdGfi-1 in CYP6D1v1-mediated insecticide resistance in the house fly. Insect Biochem. Molec. Biol. 36:387-395. 2006
- Use of quantitative real-time PCR to estimate the size of the house fly (Musca domestica) genome. Insect Biochemistry and Molecular Biology. 15:835-837. 2006
- A cline in frequency of autosomal males is not associated with insecticide resistance in house fly. Journal of Economic Entomology. 98:171-176. 2005
- Insecticide resistance in Culex pipiens from New York. J Am Mosq Cont Assoc. 21:305-309. 2005
- Insecticide susceptibility of Aedes aegypti and Aedes albopictus across Thailand. Journal of Medical Entomology. 42:821-825. 2005
- Evolutionary plasticity of monooxygenase-mediated resistance. Pesticide Biochemistry and Physiology. 78:171-178. 2004
- Indoxacarb resistance in the house fly, Musca domestica. Pesticide Biochemistry and Physiology. 80:106-112. 2004
- Insecticide resistant strains of house flies, Musca domestica show limited cross-resistance to chlorfenapyr. J. Pestic. Sci. 29:124-126. 2004
- Botanical insecticides for controlling agricultural pests : piperamides and the Colorado potato beetle Leptinotarsa decemlineata Say (Coleoptera: Chrysomelidae). Archives of Insect Biochemistry and Physiology. 54:212-225. 2003
- Genetics and mechanisms of permethrin resistance in the YPER strain of house fly. Pesticide Biochemistry and Physiology. 73:27-36. 2003
- Induction of P450 monooxygenases in the German cockroach Blattella Germanica L. Archives of Insect Biochemistry and Physiology. 53:119-124. 2003
- Spinosad resistance in the house fly, Musca domestica, is due to a recessive factor on autosome 1. Pesticide Biochemistry and Physiology. 75:1-7. 2003
- The house fly aliesterase gene (MdαE7) is not associated with insecticide resistance or P450 expression in three strains of house fly. Insect Biochemistry and Molecular Biology. 33:139-144. 2003
- The CYP6D1v1 allele is associated with insecticide resistance in the house fly, Musca domestica. Pesticide Biochemistry and Physiology. 72:40-44. 2002
- A house fly gene homologous to the zinc finger proto-oncogene Gfi-1. Biochem. Biophys. Res. Comm.. 283:644-647. 2001
- CYP9E2, CYP4C21 and related pseudogenes from German cockroaches, Blattella germanica: implications for molecular evolution, expression studies and nomenclature of P450s. Gene. 272:257-266. 2001
- Cloning of two novel P450 cDNAs from German cockroaches, Blattella germanica (L.): CYP6K1 and CYP6J1. Insect Molecular Biology. 10:131-137. 2001
- Cytochrome P450 CYP6L1 is specifically expressed in the reproductive tissues of adult male German cockroaches, Blattella germanica (L.). Insect Biochem. Molec. Biol.. 31:179-187. 2001
- Cytochrome P450s CYP6D3 and CYP6D1 are part of a P450 gene cluster on autosome 1 in house fly. Insect Molec. Biol.. 10:191-196. 2001
- Cytochromes P450 of insects: the tip of the iceberg. Pest Management Science. 57:958-967. 2001
- Expression and regulation of CYP6D3 in house fly, Musca domestica (L). Insect Biochemistry and Molecular Biology. 32:1-8. 2001
- Monitoring insecticide resistance in house flies (Diptera:Muscidae) from New York dairies. Pest Management Science. 57:514-521. 2001
- Monitoring insecticide resistance in house flies from New York dairies. Pest Management Science. 57:514-521. 2001
- Expression and activity of a house-fly cytochrome P450, CYP6D1, in Drosophila melanogaster. Insect Molecular Biology. 9:441-449. 2000
- Inhibition of cytochrome P450 6D1 by alkynylarenes, methylenedioxyarenes and other substituted aromatics. Pesticide Biochemistry and Physiology. 67:63-71. 2000
- Insecticide resistance in house flies from caged-layer poultry facilities. Pest Management Science. 56:1-7. 2000
- Metabolism of phenanthrene by house fly CYP6D1 and dog liver cytochrome P450. J. Biochem. Molec. Toxicol.. 14:20-25. 2000
- Over-expression of cytochrome P450 CYP6D1 in pyrethroid resistant strains of house fly from North America. Pesticide Biochemistry and Physiology. 68:34-41. 2000
- Genetic and biochemical mechanisms limiting fipronil toxicity in the LPR strain of house fly, Musca domestica. Pesticide Science. 55:988-992. 1999
- House fly cytochrome P450 CYP6D1: 5′ flanking sequences and comparison of alleles. Gene. 226:347-353. 1999
- Molecular basis of insecticide resistance: cytochromes P450. Insect Biochemistry and Molecular Biology. 29:757-777. 1999
- Susceptibility of obliquebanded leafroller (Lepidoptera: Tortricidae) populations from commercial apple orchards and an unsprayed habitat in New York to tebufenozide. Journal of Economic Entomology. 92:1251-1255. 1999
- CYP6D1 protects thoracic ganglia of house flies from the neurotoxic insecticide cypermethrin. Archives of Insect Biochemistry and Physiology. 37:57-63. 1998
- Increased transcription of CYP6D1 causes cytochrome P450-mediated insecticide resistance in house fly. Insect Biochemistry and Molecular Biology. 28:531-535. 1998
- Toxicity of spinosad to susceptible and resistant strains of house flies, Musca domestica. Pesticide Science. 54:131-133. 1998
- -Tocopherol antagonizes the toxicity of the pyrethroid insecticide permethrin in susceptible and kdr-resistant insects. Journal of Pesticide Science. 23:399-401. 1998
- Cross-Resistance to imidacloprid in strains of German cockroach (Blattella germanica) and house fly (Musca domestica). Pestic. Sci.. 49:367-371. 1997
- Functional expression of house fly (Musca domestica) cytochrome P450 CYP6D1 in yeast (Saccharomyces cerevisiae). Insect Biochemistry and Molecular Biology. 27:999-1006. 1997
- Inheritance of CYP6D1-mediated pyrethroid resistance in house fly (Diptera: Muscidae). Journal of Economic Entomology. 90:1478-1481. 1997
- Phenobarbital induction of CYP6D1 is due to a trans acting factor on autosome 2 in house flies, Musca domestica. Insect Molec. Biol.. 6:77-81. 1997
- Toxicity of fipronil to susceptible and resistant strains of German cockroaches (Dictyoptera: Blattellidae) and house flies (Diptera: Muscidae). Journal of Economic Entomology. 90:1152-1156. 1997
- Adult specific expression and induction of cytochrome P450lpr in house flies. Archives of Insect Biochemistry and Physiology. 31:313-323. 1996
- Cytochrome P450 monooxygenase-mediated resistance to insecticides. J. Pestic. Sci.. 21:241-246. 1996
- Cytochrome b5 is essential for cytochrome P450 6D1-mediated cypermethrin resistance in LPR house flies. Pesticide Biochemistry and Physiology. 55:150-156. 1996
- Genetic analysis of factors controlling elevated cytochrome P450, CYP6D1, cytochrome b5, P450 reductase and monooxygenase activities in LPR house flies, Musca domestica. Biochemical Genetics. 34:133-148. 1996
- Inhibitors of CYP6D1 in house fly microsomes. Insect Biochemistry and Molecular Biology. 26:645-649. 1996
- Phenobarbital and 3-methylcholanthrene inducible cytochromes P450 are not responsible for metabolism of deltamethrin in rat liver microsomes. Journal of Pesticide Science. 21:57-60. 1996
- Purification and characterization of cytochrome b5 reductase from the house fly, Musca domestica. Comp. Biochem. Physiol.. 113B:175-183. 1996
- Tetrotodotoxin protects German cockroaches (Dictyoptera: Blattellidae) from type I pyrethroid and carbamate insecticide poisoning. Journal of Economic Entomology. 89:51-55. 1996
- Allele-specific PCR reveals that the cytochrome P450lpr gene is on chromosome 1 in the house fly, Musca domestica. Experientia. 51:164-167. 1995
- Effects of temperature on insecticide toxicity. Reviews in Pesticide Toxicology. 3. 1995
- Genetics of resistance to pyrethroid insecticides in the house fly, Musca domestica. Pesticide Biochemistry and Physiology. 52:116-124. 1995
- Molecular mechanisms involved in increased expression of a cytochrome P450 responsible for pyrethroid resistance in the housefly, Musca domestica. Insect Molec. Biol.. 4:135-140. 1995
- Resistance to avermectins: extent, mechanisms and management implications. Annual Review of Entomology. 40:1-30. 1995
- cDNA and deduced protein sequence of CYP6D1: the putative gene for a cytochrome P450 responsible for pyrethroid resistance in house fly. Insect Biochemistry and Molecular Biology. 25:275-283. 1995
- Cytochrome b5 involvement in cytochrome P450 monooxygenase activities in house fly microsomes. Archives of Insect Biochemistry and Physiology. 27:205-216. 1994
- Detection of cytochrome b5 from the house fly Musca domestica: comparison of immunological and spectrophotometric methods. Comp. Biochem. Physiol.. 108B:209-214. 1994
- Linkage of kdr-type resistance and the para-homologous sodium channel in German cockroaches (Blattella germanica). Insect Biochemistry and Molecular Biology. 24:647-654. 1994
- Simple synthesis of pyrethroid metabolites. Journal of Agricultural and Food Chemistry. 42:1779-1782. 1994
- kdr-type resistance in insects with special reference to the German cockroach, Blattella germanica. Comp. Biochem. Physiol.. 109B:191-198. 1994
- Anti-P450lpr antiserum inhibits the activation of chlorpyrifos to chlorpyrifos oxon in house fly microsomes. Pesticide Biochemistry and Physiology. 45:228-233. 1993
- Characterization of [3H]abamectin binding in susceptible and abamectin resistant strains of house fly. Journal of Pesticide Science. 18:281-284. 1993
- Purification and characterization of a cytochrome P-450 from insecticide susceptible and resistant strains of house fly, Musca domestica L., before and after phenobarbital exposure. Archives of Insect Biochemistry and Physiology. 24:1-19. 1993
- The cytochrome P450 microsomal monooxygenases of insects: recent advances. Reviews in Pesticide Toxicology. 2:1-12. 1993
- Tissue distribution of microsomal cytochrome P-450 monooxygenases and their inducibility by phenobarbital in the insecticide resistant LPR strain of house fly, Musca domestica L.. Insect Biochemistry and Molecular Biology. 23:729-738. 1993
- [3H]batrachotoxinin A-20-alpha benzoate binding in synaptosomes from susceptible and kdr-type resistant German cockroaches, Blattella germanica (L.). Pesticide Biochemistry and Physiology. 46:141-148. 1993
- Anti-P450lpr antiserum inhibits specific monooxygenase activities in LPR house fly microsomes. J. Exp. Zool.. 264:153-158. 1992
- Biochemical characterization of hydrolytic and oxidative enzymes in insecticide resistant and susceptible strains of the German cockroach, Blattella germanica. Journal of Economic Entomology. 85:1092-1098. 1992
- Enhanced activation is the mechanism of negative cross-resistance to chlorpyrifos in the dicofol-IR strain of Tetranychus urticae (Acari: Tetrancychidae). Journal of Economic Entomology. 85:1088-1091. 1992
- In vitro induction of microsomal cytochrome P-450 monooxygenases by phenobarbital in fat bodies of adult house fly, Musca domestica L. Insect Biochemistry and Molecular Biology. 22:691-698. 1992
- Purification and characterization of cytochrome b5 from the house fly (Musca domestica). Comp. Biochem. Physiol.. 101B:209-215. 1992
- Susceptibility of house flies (Diptera: Muscidae) and five pupal parasitoids (Hymenoptera: Pteromalidae) to abamectin and seven commercial insecticides. Journal of Economic Entomology. 85:435-440. 1992
- Synergism of chlorpyrifos against German cockroach, Blattella germanica. Med. Vet. Entomol.. 6:241-243. 1992
- The role of cytochrome P450lpr in deltamethrin metabolism by pyrethroid resistant and susceptible strains of house flies. Pesticide Biochemistry and Physiology. 43:67-77. 1992
- Tissue distribution of microsomal cytochrome P-450 monooxygenases and their inducibility by phenobarbital in house fly, Musca domestica L. Insect Biochemistry and Molecular Biology. 22:699-711. 1992
- Biochemistry and genetics of abamectin resistance in the house fly. Pesticide Biochemistry and Physiology. 41:21-28. 1991
- Comparative toxicity of seven insecticides to immature stages of Musca domestica (Diptera: Muscidae) and two of its most important biological control agents: Muscidifurax raptor and Spalangia cameroni (Hymenoptera: Pteromalidae). Journal of Economic Entomology. 84:776-779. 1991
- Dicofol resistance in Tetranychus urticae (Acari: Tetranychidae): cross-resistance and pharmacokinetics. Journal of Economic Entomology. 84:41-48. 1991
- Expression of P450lpr is developmentally regulated and limited to house fly. J. Biochem. Toxicol.. 6:239-246. 1991
- Mechanisms responsible for propoxur resistance in the German cockroach, Blattella germanica (L.). Pesticide Science. 33:133-146. 1991
- Neuropharmacology and genetics of kdr-type resistance in the German cockroach, Blattella germanica (L.). Pesticide Biochemistry and Physiology. 41:159-169. 1991
- Rapid microsome preparation from limited numbers of house flies (Diptera: Muscidae). Entomologia Experimentalis et Applicata. 61:295-299. 1991
- Selection of high-level abamectin resistance from field-collected house flies, Musca domestica. Experientia. 47:288-291. 1991
- Toxicity of abamectin and hydramethylnon to insecticide-susceptible and resistant strains of German cockroach (Dictyoptera: Blattellidae). Journal of Agricultural Entomology. 8:77-82. 1991
- Autosomal sex-associated pyrethroid resistance in a strain of house fly (Diptera: Muscidae) with a male-determining factor on chromosome three. Journal of Economic Entomology. 83:686-689. 1990
- Biochemical changes in the cytochrome P450 monooxygenases of seven insecticide-resistant house fly (Musca domestica L.) strains. Pesticide Biochemistry and Physiology. 36:127-134. 1990
- Biochemistry and genetics of chlorpyrifos resistance in the German cockroach, Blattella germanica. Pesticide Biochemistry and Physiology. 38:110-121. 1990
- Evaluation of the biochemical basis of insecticide selectivity between host and parasitoid species. Journal of Environmental Entomology. 19:1722-1725. 1990
- Immunological detection of cytochrome P450 from insecticide resistant and susceptible house flies (Musca domestica). Pesticide Biochemistry and Physiology. 38:130-139. 1990
- Influence of cocoons on egg laying by colony founding carpenter ant queens (Hymenoptera: Formicidae). Annals of the Entomological Society of America. 83:1005-1009. 1990
- Insecticide toxicity, synergism, and resistance in the German cockroach, Blattella germanica (Dictyoptera: Blattellidae). Journal of Economic Entomology. 83:1698-1703. 1990
- Properties and inhibition of acetylcholinesterase in resistant and susceptible German cockroaches (Blattella germanica L.). Pesticide Biochemistry and Physiology. 38:122-129. 1990
- Uptake and distribution of 14C-permethrin in Blattella germanica by surface contact and topical application routes of exposure. Journal of Pesticide Science. 15:453-455. 1990
- An improved method for preparation, stabilization and storage of house fly (Diptera: Muscidae) microsomes. Journal of Economic Entomology. 82:1559-1563. 1989
- Comparative toxicity of fourteen insecticides to two species of carpenter ants (Hymenoptera: Formicidae). Journal of Economic Entomology. 82:1121-1124. 1989
- Cross-resistance to the biological insecticide abamectin in pyrethroid resistant house flies. Pesticide Biochemistry and Physiology. 34:27-31. 1989
- Insecticide resistance of house flies from New York dairies (Diptera: Muscidae). Journal of Agricultural Entomology. 6:53-64. 1989
- Interactions between pesticide resistance genes: model and experiment. Genetics. 123:543-551. 1989
- Microsomal cytochrome P450 monooxygenases in the house fly (Musca domestica L.): biochemical changes associated with insecticide resistance and phenobarbital induction. Pesticide Biochemistry and Physiology. 35:1-10. 1989
- Simultaneous purification of a cytochrome P-450 and cytochrome b5 from the house fly, Musca domestica L. Insect Biochemistry. 19:481-488. 1989
- Comparative toxicities of seven insecticides to house flies (Diptera: Muscidae) and Urolepis rufipes (Ashmead) (Hymenoptera: Pteromalidae). Journal of Economic Entomology. 81:804-807. 1988
- Comparative toxicity of seven insecticides to adult Spalangia cameroni Perkins. Journal of Agricultural Entomology. 5:139-145. 1988
- Pyrethroid insecticides. ISI Atlas Sci. Pharmacol.. 2:125-128. 1988
- Effect of temperature on the toxicity of S-bioallethrin and cypermethrin to susceptible and kdr-resistant Blattella germanica. (L.) (Dictyoptera: Blattellidae). Bull. Entomol. Res.. 77:431-435. 1987
- Oxidative metabolism of the GABAA receptor antagonist t-butylbicycloortho[3H]benzoate. Xenobiotica. 17:1085-1093. 1987
- Bioactive aziridine derivatives of chrysanthemate insecticides. Journal of Agricultural and Food Chemistry. 34:1057-1060. 1986
- Effect of method of application on resistance to pyrethroid insecticides in Blattella germanica (Orthoptera: Blattellidae). Journal of Economic Entomology. 79:571-575. 1986
- Insecticidal activity of substituted benzyl dichlorovinylcyclopropane carboxylates on susceptible and kdr-resistant strains of the southern house mosquito, Culex quinquefasciatus. Journal of Pesticide Science. 11:475-477. 1986
- Malathion-specific resistance in Anopheles stephensi from Pakistan. Journal of the American Mosquito Control Association. 2:29-32. 1986
- Mechanisms responsible for high levels of permethrin resistance in the house fly. Pestic. Sci.. 17:195-206. 1986
- The biochemical genetics of permethrin resistance in the Learn-PyR strain of house fly. Biochem. Genet.. 24:25-37. 1986
- Rapid development of high-level permethrin resistance in a field-collected strain of house fly (Diptera: Muscidae) under laboratory selection. Journal of Economic Entomology. 78:316-319. 1985
- Genetic analysis of permethrin resistance in the house fly, Musca domestica L. Experientia. 40:1416-1418. 1984
- Influence of temperature on knockdown, toxicity, and resistance to pyrethroids in the house fly, Musca domestica. Pesticide Biochemistry and Physiology. 21:53-62. 1984
- Picrotoxinin receptor in the central nervous system of the American cockroach: its role in the action of cyclodiene-type insecticides. Pesticide Biochemistry and Physiology. 22:117-127. 1984
- Difference in the picrotoxinin receptor between the cyclodiene-resistant and susceptible strains of the German cockroach.. Pesticide Biochemistry and Physiology. 19:157-166. 1983
- Evidence for two types of toxic actions of pyrethroids on susceptible and DDT-resistant German cockroaches. Pesticide Biochemistry and Physiology. 19:141-150. 1983
- Studies on the mechanism of permethrin resistance in Amblyseius fallacis (Acarina: Phytoseiidae) relative to previous insecticide use on apple. Journal of Economic Entomology. 76:6-10. 1983
- Multiple- and cross-resistances to insecticides in pyrethroid-resistant strains of the predatory mite, Amblyseius fallacis. Environmental Entomology. 11:161-164. 1982
- Characteristics of a DDT-induced case of cross-resistance to permethrin in Blattella germanica. Pesticide Biochemistry and Physiology. 16:21-27. 1981
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book
- Resistance to Avermectins in the House Fly, Musca domestica. Vol. 591. 1995
- Resistance to Avermectins in the House Fly, Musca domestica. Vol. 591. 1995
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booksection
- Cytochrome P450 monooxygenases and insecticide resistance: lessons from CYP6D1 2001
- Preparation of microsomes from insects and purification of CYP6D1 from house flies 1996
- Biomolecular basis for insecticide resistance classification and comparisons. Vol. 505. 1992
- Characterization of a cytochrome P450 responsible for pyrethroid resistance in the house fly. Vol. 505. 1992
- Physiological mechanisms of insecticide resistance in the German cockroach, Blattella germanica (L.). Vol. 505. 1992
- Insecticide resistance in insects. Vol. 2. 1991
- Investigating mechanisms of insecticide resistance: methods, strategies and pitfalls 1990
- Susceptibility of muscoid fly parasitoids to insecticides used in dairy facilities 1990
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chapter
- Antagonism of the GABA receptor of dieldrin-resistant houseflies by fipronil and its analogues. Synthesis and Chemistry of Agrochemicals VII. 39-50. 2007
- Monooxygenase-Mediated Insecticide Resistance: Regulation of CYP6D1 Expression. Agrochemical Resistance Extent, Mechanism and Detection. 2002
- Susceptibility of muscoid fly parasitoids to insecticides used in dairy facilities. Biocontrol of Arthropods Affecting Livestock and Poultry. 247-263. 1990
- Insect Cytochrome P450s: Thinking Beyond Detoxification 2008
- Managing pest resistance to pesticides: A challenge to New York's agriculture 1988
Teaching
teaching activities
- ENTOM-7070: Individual Study for Graduate Students - Spring 2013
- ENTOM-7090: Teaching Entomology - Spring 2013
- ENTOM-8900: Master's Level Thesis Research - Spring 2013
- ENTOM-9900: Doctoral Level Thesis Research - Spring 2013
- TOX-8900: Master's Thesis and Research - Spring 2013
- TOX-9900: Doctoral Thesis and Research - Spring 2013
- ENTOM-3070: Pesticides, the Environment, and Human Health - Fall 2012
- ENTOM-7070: Individual Study for Graduate Students - Fall 2012
- ENTOM-7090: Teaching Entomology - Fall 2012
- ENTOM-8900: Master's Level Thesis Research - Fall 2012
- ENTOM-9900: Doctoral Level Thesis Research - Fall 2012
- TOX-3070: Pesticides, the Environment, and Human Health - Fall 2012
- TOX-8900: Master's Thesis and Research - Fall 2012
- TOX-9900: Doctoral Thesis and Research - Fall 2012
- ENTOM-7070: Individual Study for Graduate Students - Spring 2012
- ENTOM-7090: Teaching Entomology - Spring 2012
- ENTOM-8900: Master's Level Thesis Research - Spring 2012
- ENTOM-9900: Doctoral Level Thesis Research - Spring 2012
- TOX-8900: Master's Thesis and Research - Spring 2012
- TOX-9900: Doctoral Thesis and Research - Spring 2012
- ENTOM-7070: Individual Study for Graduate Students - Fall 2011
- ENTOM-7090: Teaching Entomology - Fall 2011
- ENTOM-8900: Master's-Level Thesis Research - Fall 2011
- ENTOM-9900: Doctoral-Level Thesis Research - Fall 2011
- TOX-8900: Master's Thesis and Research - Fall 2011
- TOX-9900: Doctoral Thesis and Research - Fall 2011
Service
service to the profession
- Entomological Society of America Officer, Other Officer 2008 -
- Pesticide Science Society of Japan Member 1986 -
- Pesticide Science Society of Japan Member 1986 -
- American Association for the Advancement of Science Member 1985 -
- AMERICAN CHEMICAL SOCIETY Member 1982 -
- Entomological Society of America Member 1981 -
- AI-SPER-0203DF692AB00010884 Poster judge - 2009
- Entomological Society of America Poster Judge at National Meetings 2007 - 2008
- NRI-CSREES (USDA) Suborganismal Biology and Functional Genomics Panel Manager 2005 - 2006
- International Scientific Organizing Committee for 11th IUPAC International Congress of Pesticide Chemistry Committee Member 2006
- International Scientific Organizing Committee for 7th International Symposium on P450 Biodiversity and Biotechnology Committee Member 2004
- Society of Toxicology Member 1995 - 2002
- International Society for the Study of Xenobiotics Member 1998 - 2000
- Section B Symposia Committee, Entomological Society of America Committee Member 1989 - 1991
- USDA Committee NE-166 Chairperson - 1991
- USDA Committee NE-166 Officer, Secretary 1989 - 1990
reviewer or editor for
- BARD
- Consortium for Plant Biotechnology Research
- EPA
- Faculty Fellows-in-Service grant
- Hatch (Texas A&M)
- NIH Ad Hoc Review Panel for TMP Study Section
- NIH Ad Hoc Review Panel for TMP Study Section
- NSF External Reviewer
- NSF External Reviewer
- Rackham Foundation
- USDA Competitive Grants Review Panel
- USDA Competitive Grants Review Panel
- USDA Competitive Grants Review Panel
- USDA Competitive Grants Review Panel
- USDA External Reviewer
- USDA External Reviewer
- USDA External Reviewer
- USDA External Reviewer
- Welcome Trust
event host
Background
education and training
- Ph.D. in Entomology, University of California, Riverside 1985
- M.S. in Entomology, Michigan State University 1981
- B.S. in Biochemistry, Michigan State University 1979
- Grand Rapids Junior College 1977
awards and honors
- Graduate Student Selected Seminar Speaker, 2012
- Recognition Award in Insect Physiology, Biochemistry and Physiology, 2012
- Graduate Student Selected Seminar Speaker, 2007
- Graduate Student Selected Seminar Speaker, 2004
- Spring Suaray Graduate Student Invited Speaker, 2003
- Daljit S. and Elaine Sarkaria Professor of Insect Physiology and Toxicology, 2002
- Paul A. Dahm Memorial Lecturer, 1999
- Orkin Award for Research Excellence, 1997
- Prominent Achievement Award, 1996
- Merck Postdoctoral Fellowship Support Award, 1992
- Outstanding Young Alumnus, 1992
- John Henry Comstock Award, 1985
- Sigma Xi Grant-in-Aid of Research, 1984
- Chancellor Patent Fund Research Grant, 1984
- Michigan State University Graduate School Scholarship, 1981
- Grand Rapids Junior College Scholarship, 1977
Other
research keyword
- cytochrome P450
- evolution of insecticide resistance
- house fly
- insecticide toxicology
- mosquito
- nicotinic acetylcholine receptor
- sex determination
- voltage gated sodium channel