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Soderlund, David M.
Cornell Faculty Member
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Positions
- Professor, Entomology at Geneva
- Director, Entomology at Geneva
- Dept. Chairperson, Assoc, Entomology at Geneva
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Affiliations
member of graduate field
other Cornell affiliations
Research
research overview
- Insecticides are unique among environmental toxicants because they are intentionally released into the environment with the knowledge that they present a toxicity risk to nontarget species, including humans, by the same modes of action that confer their desirable insecticidal properties. Knowledge of insecticide mode of action is therefore essential to the management of the risks associated with insecticide use. Because most insecticides act on the nervous system, the major emphasis of my research program is to identify the sites of action of insecticides in the nervous system and elucidate the mode of action of insecticides acting at those sites. Specific goals of my research include the elucidation of mechanisms of toxic action for established and experimental insecticides, identification of the molecular mechanisms underlying target site-mediated resistance to insecticides, development of new research tools and strategies for the discovery of improved insect control agents, and characterization of mechanisms underlying insecticide toxicity to non-target organisms, including humans. Current research employs the molecular cloning of target site genes from insect and mammalian neuronal tissues, the transient or stable heterologous expression of target macromolecules in vertebrate or insect cells in culture, and functional and pharmacological analysis of the expressed targets ins support of these objectives.
principal investigator on
- GLOBAL RESIDUE GENERATION PROJECT WITH CORNELL UNIVERSITY awarded by FOREIGN AGRICULTURAL SERVICE USDA 2012 - 2013
- INSECTICIDE ACTION AT THE LOCAL ANESTHETIC RECEPTOR awarded by ENVIRONMENTAL HEALTH SCIENCES NIH 2006 - 2012
- IR4 MINOR CROP PEST MANAGEMENT PROGRAM awarded by NATIONAL INSTITUTE OF FOOD AND AGRICULTURE-USDA 2012 - 2013
- MOLECULAR DETERMINANTS OF PYRETHROID NEUROTOXICITY awarded by ENVIRONMENTAL HEALTH SCIENCES NIH 2007 - 2013
- NORTHEAST REGION CENTER FOR THE IR-4 MINOR CROP PEST MANAGEMENT PROGRAM awarded by NATIONAL INSTITUTE OF FOOD AND AGRICULTURE-USDA 2011 - 2013
area(s) of concentration/expertise
keywords
- insecticide resistance
- insecticides
- molecular neurobiology
- pyrethroids
- toxicology
submitted impact statement
Publications
individual publications
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academic article
- Compound-specific effects of mutations at V787 in DII-S6 of Nav1.4 sodium channels on the action of sodium channel inhibitor insecticides. NeuroToxicology. 33:1381-1389. 2012
- Differential state-dependent modification of inactivation-deficient Nav1.6 sodium channels by the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin. NeuroToxicology. 33. 2012
- Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances. Archives of Toxicology. 86:165-181. 2012
- Role of the local anesthetic receptor in the state-dependent inhibition of voltage-gated sodium channels by the insecticide metaflumizone. Molecular Pharmacology. 81:366-374. 2012
- Coexpression with auxiliary β subunits modulates the action of tefluthrin on rat Nav1.6 and Nav1.3 sodium channels. Pesticide Biochemistry and Physiology. 101:256-264. 2011
- Differential state-dependent modification of rat Nav1.6 sodium channels expressed in human embryonic kidney (HEK293) cells by the pyrethroid insecticides tefluthrin and deltamethrin . Toxicol Appl Pharmacol. 257:377-87. 2011
- Divergent actions of the pyrethroid insecticides S-bioallethrin, tefluthrin and deltamethrin on rat Nav1.6 sodium channels. Toxicology and applied pharmacology. 247:229-237. 2010
- Human Embryonic Kidney (HEK293) Cells Express Endogenous Voltage-Gated Sodium Currents and Nav1.7 Sodium Channels. Neuroscience Letters. 469:268-272. 2010
- State-dependent modification of voltage-gated sodium channels by pyrethroids. Pesticide Biochemistry and Physiology. 97:78-86. 2010
- The ligand-gated chloride channel gene family of Drosophila melanogaster. Pesticide Biochemistry and Physiology. 97:140-148. 2010
- Cloning and maintenance of the housefly sodium channel gene using low copy number vector and two sequential host strains. J. Asia-Pac. Entomol.. 12:51-53. 2009
- Evidence for a separate mechanism of toxicity for the Type I and Type II pyrethroid insecticides. Neurotoxicology. 30. 2009
- Human and rat Nav1.3 voltage-gated sodium channels differ in inactivation properties and sensitivity to the pyrethroid insecticide tefluthrin. NeuroToxicology. 30:81-89. 2009
- The ligand-gated chloride channel gene family of Drosophila melanogaster. Pesticide Biochemistry and Physiology. doi:1016/j.pestbp.2009.09.002:9. 2009
- Pyrethroids, knockdown resistance and sodium channels. Pest Management Science. 64:610-616. 2008
- Three mutations identified in the voltage-sensitive sodium channel alpha-subunit gene of permethrin-resistant human head lice reduce the permethrin sensitivity of house fly Vssc1 sodium channels expressed in Xenopus oocytes. Insect Biochemistry and Physiology. 38:296-306. 2008
- Point mutations at the local anesthetic receptor site modulate the state-dependent block of rat Nav1.4 sodium channels by pyrazoline-type insecticides. NeuroToxicology. 28:655-663. 2007
- Differential sensitivity of rat sodium channel isoforms to pyrazoline-type insecticides. Toxicology and Applied Pharmacology. 214:209-217. 2006
- Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Nav1.8 sodium channels expressed in Xenopus oocytes. Toxicology and Applied Pharmacology. 211:233-244. 2006
- Action of pyrazoline-type insecticides at neuronal target sites. Pesticide Biochemistry and Physiology. 81:136-143. 2005
- Actions of pyrazoline-type insecticides at the sodium channel local anesthetic receptor. Society for Neuroscience Abstracts. 31. 2005
- State-dependent block of rat Nav1.4 sodium channels expressed in Xenopus oocytes by pyrazoline-type insecticides. NeuroToxicology. 26:397-406. 2005
- Cyclosporin A and deltamethrin block the downregulation of Nav1.8 sodium channels expressed in Xenopus oocytes. Neuroscience Letters. 367:389-393. 2004
- Differential sensitivity of mammalian sodium channel isoforms to pyrazoline-type insecticides. Society for Neuroscience Abstracts. 30. 2004
- The molecular biology of knockdown resistance. Insect Biochemistry and Molecular Biology. 33:563-577. 2003
- Developmental regulation of alternative exon usage in the house fly Vssc1 sodium channel gene. Invertebrate Neuroscience. 4:125-133. 2002
- Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment. Toxicology. 171:3-59. 2002
- Point mutations in homology domain II modify the sensitivity of rat Nav1.8 sodium channels to the pyrethroid insecticide cismethrin. NeuroToxicology. 22:755-765. 2001
- Potent actions of the pyrethroid insecticides cismethrin and cypermethrin on rat tetrodotoxin-resistant peripheral nerve (SNS/PN3) sodium channels expressed in Xenopus oocytes. Pesticide Biochemistry and Physiology. 70:52-61. 2001
- The V410M mutation associated with pyrethroid resistance in Heliothis virescens reduces the pyrethroid sensitivity of house fly sodium channels expressed in Xenopus oocytes. Insect Biochemistry and Molecular Biology. 31:19-29. 2001
- Cloning and functional characterization of a putative sodium channel auxiliary subunit from the house fly (Musca domestica). Insect Biochemistry and Molecular Biology. 30:479-487. 2000
- Differential sensitivity of sodium channel isoforms and sequence variants to pyrethroid insecticides. NeuroToxicology. 21:127-138. 2000
- Knockdown resistance to DDT and pyrethroids in the house fly (Musca domestica L.): from genetic trait to molecular mechanism. Annals Entomol. Soc. Amer. 92:909-915. 1999
- Molecular analysis of kdr-like resistance in a permethrin-resistant strain of Colorado potato beetle. Pesticide Biochemistry and Physiology. 63:63-75. 1999
- Mutations in the house fly Vssc1 sodium channel gene associated with super-kdr resistance abolish the pyrethroid sensitivity of Vssc1/tipE sodium channels expressed in Xenopus oocytes. Insect Biochemistry and Molecular Biology. 29:185-194. 1999
- Action of the pyrethroid insecticide cypermethrin on rat brain IIA sodium channels expressed in Xenopus oocytes. NeuroToxicology. 19:823-832. 1998
- Actions of the pyrethroid insecticides cismethrin and cypermethrin on house fly Vssc1 sodium channels expressed in Xenopus oocytes. Archives of Insect Biochemistry and Physiology. 38:126-136. 1998
- Structure-activity relationships for the action of dihydropyrazole insecticides on mouse brain sodium channels. Pesticide Biochemistry and Physiology. 60:177-185. 1998
- The L1014F point mutation in the house fly Vssc1 sodium channel gene confers knockdown resistance to pyrethroids. Insect Biochemistry and Molecular Biology. 27:807-812. 1997
- Characterization of voltage-sensitive sodium channel gene coding sequences from insecticide-susceptible and knockdown-resistant house fly strains. Insect Biochemistry and Molecular Biology. 26:319-326. 1996
- PCR-based homology probing reveals a family of GABA receptor-like genes in Drosophila melanogaster. Insect Biochemistry and Molecular Biology. 24:363-371. 1994
- Tight genetic linkage between the kdr insecticide resistance trait and a voltage-sensitive sodium channel gene in the house fly. Proceedings at the National Academy of Science USA. 91:2483-2487. 1994
- Actions of Avermectin Analogs on γ-Aminobutyric Acid (GABA)-Sensitive and GABA-Insensitive Chloride Channels in Mouse Brain . Pesticide Biochemistry and Physiology. 47:178-184. 1993
- Binding of [3H]batrachotoxinin A-20-alpha-benzoate and [3H]saxitoxin to receptor sites associated with sodium channels in trout brain synaptoneurosomes. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology. 105:231-238. 1993
- Characterization of a putative gamma-aminobutyric acid (GABA) receptor beta subunit gene from Drosophila melanogaster. Biochemical and Biophysical Research Communications. 193:474-482. 1993
- Inhibition of octopamine-stimulated adenylate cyclase activity in twospotted mites by dicofol and related diphenylcarbinol acaricides. Pesticide Biochemistry and Physiology. 46:228-235. 1993
- Structure-Activity Relationships for Pyrethroids and DDT Analogs as Modifiers of [3H]Batrachotoxinin A 20α-Benzoate Binding to Mouse Brain Sodium Channels . Pesticide Biochemistry and Physiology. 45:130-140. 1993
- Interaction of naturally occurring neurotoxins and the pyrethroid insecticide deltamethrin with rainbow trout (Oncorhynchus mykiss) brain sodium channels. Environmental Toxicology and Chemistry. 11:677-685. 1992
- Mechanisms of action of ibogaine and harmaline congeners based on radioligand binding studies. Brain Res. 571:242-247. 1992
- Metabolic considerations in pyrethroid design. Xenobiotica. 22:1185-1194. 1992
- Activation of gamma-aminobutyric acid insensitive chloride channels in mouse brain synaptic vesicles by avermectin B1a. J. Biochem. Toxicol. 6:283-292. 1991
- Effects of avermectins on GABA-sensitive and GABA-insensitive chloride channels in mouse brain synaptic vesicles. Pesticide Science. 33:131-132. 1991
- Inhibition of [3H]batrachotoxinin A 20-α-benzoate binding to mouse brain sodium channels by the dihydropyrazole insecticide RH 3421. Pesticide Biochemistry and Physiology. 41:265-273. 1991
- Mode of action of dihydropyrazoles on sodium channels. Pesticide Science. 33:128-129. 1991
- PCR-generated conspecific sodium channel gene probe for the house fly homologue of the para locus of Drosophila melanogaster. Archives of Insect Biochemistry and Physiology. 16:45-53. 1991
- Pharmacological characterization of trout brain sodium channels. Pesticide Science. 33:129-131. 1991
- Prolonged exposure to GABA activates GABA-gated chloride channels in the presence of channel-blocking convulsants. Comp Biochem Physiol C. 99:397-402. 1991
- RH 3421, an insecticidal dihydropyrazole, inhibits sodium channel-dependent sodium uptake in mouse brain preparations. Pesticide Biochemistry and Physiology. 39:130-137. 1991
- Action of insecticidal N-alkylamides at Site 2 of the voltage-sensitive sodium channel. Journal of Agricultural and Food Chemistry. 38:1724-1728. 1990
- Activation of sodium channels and inhibition of [3H]batrachotoxinin A-20-alpha-benzoate binding by an N-alkylamide neurotoxin. Mol. Pharmacol. 36:280-284. 1989
- Allosteric enhancement by DDT of the binding of [3H]batrachotoxinin A-20-α-benzoate to sodium channels. Pesticide Biochemistry and Physiology. 33:276-282. 1989
- Binding of [3H]batrachotoxinin A-20-alpha-benzoate to a high affinity site associated with house fly head membranes. Comp Biochem Physiol C. 94:255-260. 1989
- Knockdown resistance to dichlorodiphenyl-trichloroethane and pyrethroid insecticides in the napts mutant of Drosophila melanogaster is correlated with reduced neuronal sensitivity. Archives of Insect Biochemistry and Physiology. 10:293-302. 1989
- Molecular neurobiology: implications for insecticide action and resistance. Pesticide Science. 26:359-374. 1989
- Neurotoxic actions of pyrethroid insecticides. Annu. Rev. Entomol. 34:77-96. 1989
- Allosteric interactions of insecticides with the [3H]BTX-B binding site of the voltage-sensitive sodium channel. Pestic. Sci. 24:280-282. 1988
- Binding of [3H]saxitoxin to head membrane preparations from susceptible and knockdown-resistant houseflies. Pesticide Biochemistry and Physiology. 32:217-223. 1988
- Pyrethroid insecticides and DDT modify alkaloid-dependent sodium channel activation and its enhancement by sea anemone toxin. Mol. Pharmacol. 33:543-550. 1988
- The DDT/pyrethroid recognition site of the voltage-sensitive sodium channel: interactions with alkaloid activators and sea anemone toxin. Pestic. Sci. 24:78-79. 1988
- Differences in the action of avermectin B1a on the GABAA receptor complex of mouse and rat. Biochem. Biophys. Res. Commun. 146:692-698. 1987
- Metabolism of fenvalerate in resistant Colorado potato beetles. Journal of Agricultural and Food Chemistry. 35:100-105. 1987
- Pharmacological characterization of the voltage-dependent sodium channels of rainbow trout brain synaptosomes. Brain Res. 437:77-82. 1987
- Inhibition of gamma-aminobutyric acid-stimulated chloride flux in mouse brain vesicles by polychlorocycloalkane and pyrethroid insecticides. NeuroToxicology. 7:11-20. 1986
- Neurotoxic insecticides inhibit GABA-dependent chloride uptake by mouse brain vesicles. Biochem. Biophys. Res. Commun. 133:37-43. 1985
- Pyrethroid insecticides: potent, stereospecific enhancers of mouse brain sodium channel activation. Pesticide Biochemistry and Physiology. 24:200-206. 1985
- Pyrethroid-receptor interactions: stereospecific binding and effects on sodium channels in mouse brain preparations. NeuroToxicology. 6:35-46. 1985
- Reactions of precocene II epoxide with model nucleophiles. Journal of Agricultural and Food Chemistry. 33:406-411. 1985
- Hydrolysis of pyrethroid insecticides by soluble mouse brain esterases. Toxicol. Appl. Pharmacol. 74:390-396. 1984
- Monooxygenase activity of tobacco budworm (Heliothis virescens F.) larvae: Tissue distribution and optimal assay conditions for the gut activity. Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 79:407-411. 1984
- Mouse brain synaptosomal sodium channels: Activation by aconitine, batrachotoxin and veratridine, and inhibition by tetrodotoxin. Comp Biochem Physiol C. 77:267-271. 1984
- Effects of non-neural mechanisms on pyrethroid structure-activity relationships. J Environ Sci Health B. 18:15-27. 1983
- Pharmacokinetics of cis- and trans-substituted pyrethroids in the American cockroach. Pesticide Biochemistry and Physiology. 20:161-168. 1983
- Polyethylene glycol pretreatment reduces pyrethroid adsorption to glass surfaces. Journal of Agricultural and Food Chemistry. 31:1127-1129. 1983
- Radiosynthesis of high specific activity precocene II. J. Labelled Comp. Radiopharm. 20:791-796. 1983
- Receptor-like stereospecific binding of a pyrethroid insecticide to mouse brain membranes. Life Science. 33:261-267. 1983
- Varying susceptibility to methomyl and permethrin in widely separated cabbage looper (Lepidoptera: Noctuidae) populations within eastern North America. Journal of Economic Entomology. 76:987-989. 1983
- Biogenic amine acetylation: No detectable circadian rhythm in whole brain homogenates of the insect Ostrinia nubilalis. Cellular and Molecular Life Sciences. 38:302-303. 1982
- Biosynthesis of the sesquiterpenoid skeleton of juvenile hormone 3 by Dysdercus fasciatus corpora allata in vitro. Journal of Experimental Zoology. 223:295-298. 1982
- Liquid chromatographic determination and resolution of the enantiomers of the acid moieties of pyrethroid insecticides as their (-)-1-(1-phenyl)ethylamide derivatives. Journal of Chromatography. 248:143-149. 1982
- Natural and synthetic allatotoxins: Suicide substrates for juvenile hormone biosynthesis. Science. 217:647-648. 1982
- Selective inhibition of separate esterases in rat and mouse liver microsomes hydrolyzing malathion, trans-permethrin, and cis-permethrin. Pesticide Biochemistry and Physiology. 17:162-169. 1982
- Ovarian sequestration of 14C-inulin by an insect: An index of vitellogenesis. Journal of Insect Physiology. 27:379-382. 1981
- An improved procedure for the preparation of 2,2-dimethyl-4-chromanones. Synthesis. 1980:725-727. 1980
- In vitro N-acetylation of biogenic amines by tissues of the European corn borer, Ostrinia nubilalis Hubner. Insect Biochemistry. 10:375-380. 1980
- Laboratory and field tests of insecticides against the apple maggot. Journal of Economic Entomology. 73:752-754. 1980
- Precocene II metabolism in insects: Synthesis of potential metabolites and identification of initial in vitro biotransformation products. Journal of Agricultural and Food Chemistry. 28:724-731. 1980
- Pyrethroid-hydrolyzing esterases in southern armyworm larvae: Tissue distribution, kinetic properties, and selective inhibition. Pesticide Biochemistry and Physiology. 14:282-289. 1980
- Synthetic pyrethroids: Their development and mode of action against fruit pests. Proc. New York State Horticultural Society. 125:108-113. 1980
- Pharmacokinetic behavior of enantiomeric pyrethroid esters in the cockroach, Periplaneta americana. Pesticide Biochemistry and Physiology. 12:38-48. 1979
- Insecticidal activity of the pyrethrins and related compounds, Part XII; relative potencies of isomeric cyano-substituted 3-phenoxybenzyl esters. Pesticide Science. 9:112-116. 1978
- The pyrethrins and related compounds, Part XXII; preparation of isomeric cyano-substituted 3-phenoxybenzyl esters. Pesticide Science. 9:105-111. 1978
- Effects of pyrethroid structure on rates of hydrolysis and oxidation by mouse liver microsomal enzymes. Pesticide Biochemistry and Physiology. 7:391-401. 1977
- Separation and analysis of the pyrethrins by combined gas chromatography - chemical ionization mass spectrometry. J. Assoc. Offic. Anal. Chem. 60:685-689. 1977
- Structure-biodegradability relationships in pyrethroid insecticides. Arch. Environ. Contam. Toxicol. 3:491-500. 1975
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booksection
- Agents affecting sodium channels. Vol. 1. 2001
- The molecular mechanism of knockdown resistance 2001
- Expression of cloned house fly sodium channels in Xenopus oocytes: action of pyrethroids and analysis of resistance-associated mutations 1999
- Interactions of N-alkylamides with voltage-sensitive sodium channels 1992
- Chemical strategies for resistance management 1986
- Semiochemistry 1985
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chapter
- Pyrethroid actions on sodium channels: isoform and species specificity. Parameters for Pesticide QSAR and PBPK/PD Models for Human Risk Assessment. 217-228. 2012
- Toxicology and mode of action of pyrethroid insecticides. Hayes' Handbook of Pesticide Toxicology. 1665-1686. 2010
- Sodium channels. Comprehensive Molecular Insect Science. 1-24. 2005
- Pyrethroids and sodium channels. Neurotox '03: Neurotoxological Targets from Functional Genomics and Proteomics. 79-96. 2004
- Molecular mechanisms of insecticide resistance. Molecular Mechanisms of Resistance to Agrochemicals. 21-56. 1997
- Actions of insecticides on sodium channels: multiple target sites and site-specific resistance. Molecular Action of Insecticides on Ion Channels. 97-108. 1995
- Mode of action of pyrethrins and pyrethroids. Pyrethrum Flowers: Production, Chemistry, Toxicology and Uses. 217-233. 1995
- Structural and functional characterization of insect genes encoding ligand-gated chloride channel subunits. Molecular Action of Insecticides on Ion Channels. 205-215. 1995
- Molecular mechanisms of insecticide resistance. Pesticide Resistance in Arthropods. 58-96. 1990
- Molecular genetic approach to the study of target site resistance to pyrethroids and DDT in insects. Biotechnology in Crop Protection. 199-214. 1988
- Enhancement of veratridine-dependent sodium channel activation by pyrethroids and DDT analogs. Sites of Action for Neurotoxic Pesticides. 251-261. 1987
- Neurotoxic insecticides as antagonists of GABAA receptor function. Sites of Action for Neurotoxic Pesticides. 97-106. 1987
- Mammalian toxicology of pyrethroids. Progress in Pesticide Biochemistry and Toxicology. 193-248. 1985
- Metabolism of pyrethrins and pyrethroids in insects. Progress in Pesticide Biochemistry and Toxicology. 401-435. 1983
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conference paper
- Molecular neurobiology and insecticide discovery. Eighth International Congress of Pesticide Chemistry: Options 2000. 309-319. 1995
- Isolation of insect genes coding for voltage-sensitive sodium channels and ligand-gated chloride channels by PCR-based homology probing. Neurotox '91: Molecular Basis of Drug and Pesticide Action. 271-283. 1992
- Pharmacological characterization of insecticide-binding domains of the voltage-sensitive sodium channel. Insecticide Action: From Molecule to Organism. 85-97. 1989
- Neuropharmacology and molecular genetics of nerve insensitivity resistance to pyrethroids. Molecular basis of drug & pesticide action: proceedings of Neurotox '88, molecular basis of drug & pesticide action, University of Nottingham, England, 10-15 April 1988. 553-561. 1988
- Pharmacokinetic approaches to the action of pyrethroids in insects. Pesticide Chemistry, Human Welfare and the Environment: Proceedings of the 5th International Congress of Pesticide Chemistry, Kyoto, Japan, 29 August. 69-74. 1983
- Chemistry and action of the precocenes. Regulation of insect development and behavior: International Conference, Karpacz, Poland, June 23-28 1980, Part 1. 309-322. 1981
- Mechanisms of selectivity in the action of the precocenes. Juvenile hormone biochemistry: action, agonism, and antagonism: proceedings of the Third International Congress on Juvenile Hormone Biochemistry--Action, Agonism, and Antagonism, held in Brighton, United Kingdom, July 7-10, 1981. 353-361. 1981
- Pharmacokinetic modifications of intrinsic insecticide activity. Insect Neurobiology and Pesticide Action (Neurotox '79). 449-455. 1980
- Stereospecificity of pyrethroid metabolism in mammals. Synthetic pyrethroids: a symposium sponsored by the Division of Pesticide Chemistry at the 172nd meeting of the American Chemical Society, San Francisco, Calif., Aug. 30-31, 1976. 173-185. 1977
- Substrate specificity of mouse liver microsomal enzymes in pyrethroid metabolism. Synthetic pyrethroids: a symposium sponsored by the Division of Pesticide Chemistry at the 172nd meeting of the American Chemical Society, San Francisco, Calif., Aug. 30-31, 1976. 162-172. 1977
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document part
- Actions of pyrazoline-type insecticides at the sodium channel local anesthetic receptor 2005
- Differential sensitivity of mammalian sodium channel isoforms to pyrazoline-type insecticides 2004
- Actions of the pyrethroid insecticide tefluthrin on rat sodium channel isoforms 2003
- Indoxacarb and its N-decarbomethoxyllated metabolite DCJW block cloned rat sodium channels expressed in Xenopus oocytes 2003
- Actions of cismethrin, deltamethrin and cyclosporin A on Nav1.8 sodium channels expressed in Xenopus oocytes 2002
- Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment. 319. 2002
- Actions of pyrethroid insecticides on individual sodium channel isoforms. 622. 2000
- The ligand-gated chloride channel gene family of Drosophila. 1901. 2000
- Cloning and functional characterization of a putative sodium channel auxiliary subunit from the house fly. 1733. 1999
- Functional analysis of pyrethroid resistance-associated mutations inserted into rat peripheral nerve sodium channels. 1730. 1999
- Functional analysis of resistance-associated mutations in house fly sodium channels. 1821. 1998
- A point mutation in a house fly sodium channel gene confers insecticide resistance. 910. 1997
- Action of pyrethroid insecticides on house fly sodium channels expressed in Xenopus oocytes. 910. 1997
- Structure-activity relationship of deltamethrin analogs on sodium channels expressed in Xenopus oocytes. 60. 1996
- Actions of pyrethroid insecticides on sodium channels expressed in Xenopus oocytes. 1821. 1995
- Characterization of sodium channel genes from insecticide-susceptible and insecticide-resistant house flies. 1824. 1995
- Characterization of a putative gamma-aminobutyric acid (GABA) receptor beta subunit gene from Drosophila melanogaster. 478. 1993
- Characterization of an unusual member of the ligand-gated chloride channel gene family of Drosophila melanogaster. 489. 1993
- Development of probes for the isolation of presumptive voltage-sensitive sodium channel genes from insects 1990
- Isolation of presumptive voltage-sensitive sodium channel genes from insects. 346-347. 1990
- N-Alkylamide neurotoxins act at two binding domains on the voltage-sensitive sodium channel. 198. 1989
- Interaction of an insecticidal isobutylamide with voltage-sensitive sodium channels. 837. 1988
- Pyrethroid insecticides and DDT modify alkaloid-dependent activation of the voltage-sensitive sodium channel. 93. 1987
- Neurotoxic insecticides antagonize chloride uptake at the mammalian GABAA receptor-chloride ionophore complex. 1075. 1986
featured in archived article
Teaching
teaching activities
- TOX-8900: Master's Thesis and Research - Spring 2013
- TOX-9900: Doctoral Thesis and Research - Spring 2013
- TOX-8900: Master's Thesis and Research - Fall 2012
- TOX-9900: Doctoral Thesis and Research - Fall 2012
- TOX-8900: Master's Thesis and Research - Spring 2012
- TOX-9900: Doctoral Thesis and Research - Spring 2012
- TOX-8900: Master's Thesis and Research - Fall 2011
- TOX-9900: Doctoral Thesis and Research - Fall 2011
Service
service to the profession
- Project Management Committee, IR-4 Program Committee Member 1999 -
reviewer or editor for
Background
education and training
- Ph.D. in Entomology, University of California, Berkeley 1976
- B.S. in Biology, Pacific Lutheran University 1971
awards and honors
Other
research keyword
- insecticide resistance
- insecticides
- molecular neurobiology
- pyrethroids
- toxicology