administrative responsibilities
- Director of Undergraduate Studies for Genetics and Development
Networks
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Co-Investigators
Map Of Science
Barbash, Daniel A.
Cornell Faculty Member
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Positions
- Associate Professor, Molecular Biology and Genetics (MBG), College of Agriculture and Life Sciences (CALS)
Research Areas
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Affiliations
member of graduate field
other Cornell affiliations
Research
research overview
- Genetics and molecular evolution of interspecific hybrid incompatibilities; molecular evolution of rapidly evolving germ-line genes; transposable element dynamics
principal investigator on
- COLLABORATIVE RESEARCH: DROSOPHILA ULTRACONSERVED ELEMENTS: FUNCTION AND EVOLUTION awarded by DIRECTORATE FOR BIOLOGICAL SCIENCES NSF 2011 - 2014
- EVOLUTION OF PIRNAS AND GERMLINE TRANSPOSON CONTROL IN DROSOPHILA awarded by NATL INST OF HEALTH DHHS 2010 - 2013
- MOLECULAR GENETICS OF DROSOPHILA HYBRID LETHALITY awarded by NATL INST OF GENERAL MEDICAL SCIENCES, NIH 2009 - 2013
co-principal investigator on
area(s) of concentration/expertise
keywords
- genomics
- molecular evolution; genetics
submitted impact statement
Publications
individual publications
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academic article
- An indel polymorphism in the hybrid incompatibility gene Lethal hybrid rescue of Drosophila is functionally relevant. . Genetics. 192:683-91. 2012
- Cis-by-Trans regulatory divergence causes the asymmetric lethal effects of an ancestral hybrid incompatibility gene. . PLoS Genetics. 192:683-691. 2012
- Drosophila interspecific hybrids phenocopy piRNA-pathway mutants. . PLoS Biology. 10. 2012
- Comment on "A test of the snowball theory for the rate of evolution of hybrid incompatibilities". Science. 333:1576. 2011
- Functional conservation of the Drosophila hybrid incompatibility gene Lhr. BMC Evolutionary Biology. 11:57. 2011
- The genetics of hybrid incompatibilities. Annual Review of Genetics. 45:331-355. 2011
- 90 years of D. melanogaster hybrids. Genetics. 186:1-8. 2010
- Evolutionary biology: Expanding islands of speciation (News and Views article) . Nature. 465:1019-20. 2010
- Genetic testing of the hypothesis that hybrid male lethality results from a failure in dosage compensation. Genetics. 184:313-316. 2010
- Reduced fertility of Drosophila melanogaster Hybrid male rescue (Hmr) mutant females is partially complemented by Hmr orthologs from sibling species. Genetics. 181:1437-1450. 2009
- Species-specific heterochromatin prevents mitotic chromosome segregation to cause hybrid lethality in Drosophila. PLoS Biology. 7. 2009
- The pachytene checkpoint and its relationship to evolutionary patterns of polyploidization and hybrid sterility. Heredity. 102:24-30. 2009
- Abundant and species-specific DINE-1 transposable elements in 12 Drosophila genomes. Genome Biology. 9. 2008
- Clash of the genomes. Academy of Entrepreneurship Journal. 135:1002-1003. 2008
- Recurrent positive selection of the Drosophila hybrid incompatibility gene Hmr. Molecular Biology and Evolution. 25:2421-2430. 2008
- Developmental and cell cycle progression defects in Drosophila hybrid males. Genetics. 177:2233-2241. 2007
- Distorted sex ratios - a window into RNAi-mediated silencing. PLoS Biology. 5. 2007
- Drosophila 12 Genomes Consortium: Evolution of genes and genomes on the Drosophila phylogeny. Nature. 450:203-218. 2007
- Evolution of hydra, a recently evolved testis-expressed gene with nine alternative first exons in Drosophila melanogaster. PLoS Genetics. 3. 2007
- Lethality in Drosophila melanogaster/Drosophila simulans species hybrids is not associated with substantial transcriptional misregulation. Journal of experimental zoology Part B Molecular and developmental evolution. 308B:74-84. 2007
- Nup96-dependent hybrid lethality occurs in a subset of species from the simulans clade of Drosophila. Genetics. 176:543-552. 2007
- Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila. Science. 314:1292-1295. 2006
- A new hybrid rescue allele in Drosophila melanogaster. Genetica. 120:261-266. 2004
- Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus. PLoS Biology. 2. 2004
- A novel system of fertility rescue in Drosophila hybrids reveals a link between hybrid lethality and female sterility. Genetics. 163:217-226. 2003
- A rapidly evolving MYB-related protein causes species isolation in Drosophila. Proceedings at the National Academy of Science USA. 100:5302-5307. 2003
- The Drosophila melanogaster Hybrid male rescue gene causes lethality in both male and female species hybrids. Genetics. 154:1747-1771. 2000
- . Functioning of the Drosophila integral U1/U2 protein Snf independent of U1 and U2 small nuclear ribonucleoprotein particles is revealed by snf+ gene dose effects. Proceedings at the National Academy of Science USA. 96:14451-14458. 1999
- Stress sensitive B encodes an adenine nucleotide translocase in Drosophila melanogaster. Genetics. 153:891-903. 1999
- Chemical shift mapping of the RNA-binding interface of the multiple-RBD protein Sex-lethal. Biochemistry. 36:14306-14317. 1997
- Hedgehog acts by distinct gradient and signal relay mechanisms to organise cell type and cell polarity in the Drosophila abdomen. Development. 124:2155-2165. 1997
- Hedgehog organises the pattern and polarity of epidermal cells in the Drosophila abdomen. Development. 124:2143-2154. 1997
- Genetic and molecular analysis of the autosomal component of the primary sex determination signal of Drosophila melanogaster. Genetics. 141:1451-1471. 1995
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conference paper
- Do defects in heterochromatin structure cause hybrid lethality? . 50th Annual Drosophila Research Conference. 2009
- Heterochromatin as a facilitator of speciation: an incompatibility between a satellite and its associated binding protein causes hybrid lethality in Drosophila. . 50th Annual Drosophila Research Conference. 2009
- Investigating the hybrid incompatibility protein LHR through interactions with heterochromatin proteins. . 50th Annual Drosophila Research Conference. 2009
- Species-specific heterochromatin as a cause of reproductive isolation between Drosophila melanogaster and D. simulans. Society for Molecular Biology and Evolution. 2009
- Testing the functional consequences of adaptive protein evolution at the Drosophila germline stem cell regulatory gene bag of marbles. Society for Molecular Biology and Evolution. 2009
- Testing the functional consequences of adaptive protein evolution at the Drosophila germline stem cell regulatory gene bag of marbles.. 50th Annual Drosophila Research Conference. 2009
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Teaching
teaching overview
- Molecular Evolution
teaching activities
Service
Background
education and training
- Ph.D. in Genetics, Univ. of California, Berkeley 1995
- B.S. in Biology, MIT 1989
awards and honors
Other
research keyword
- genomics
- molecular evolution; genetics